Uehara S, Naganuma T, Tsuiki A, Kyono K, Hoshiai H, Suzuki M
Obstet Gynecol. 1985 Jul;66(1):19-23.
Steroid concentrations were measured in follicular fluid obtained from patients fertilized in vitro. Progesterone and estradiol-17 beta concentrations showed positive correlations with the growth of follicles, whereas the testosterone concentration had negative correlations not only with follicle growth but also with progesterone and estradiol-17 beta concentrations. The testosterone concentration was significantly lower in follicles with cleaved oocytes than in those with uncleaved oocytes or those with cleaved but degenerated oocytes. After the luteinizing hormone (LH) surge, the fluid contained significantly higher progesterone and lower testosterone concentrations than after human chorionic gonadotropin (hCG) injection. These results indicate that steroid concentrations vary with the growth of follicles, and that the oocyte that can cleave well tends to be associated with a low testosterone concentration. Furthermore, the LH surge seems to provide a better hormonal condition for cleavage than does hCG injection.
对体外受精患者的卵泡液中的类固醇浓度进行了测量。孕酮和雌二醇-17β浓度与卵泡生长呈正相关，而睾酮浓度不仅与卵泡生长呈负相关，还与孕酮和雌二醇-17β浓度呈负相关。有卵裂的卵泡中的睾酮浓度显著低于未卵裂的卵泡或卵裂但退化的卵泡中的睾酮浓度。促黄体生成素（LH）峰出现后，卵泡液中孕酮浓度显著升高，睾酮浓度低于注射人绒毛膜促性腺激素（hCG）后。这些结果表明，类固醇浓度随卵泡生长而变化，能够良好卵裂的卵母细胞往往与低睾酮浓度相关。此外，LH峰似乎比hCG注射为卵裂提供了更好的激素条件。
