Hauth J C, Gilstrap L C, Hankins G D, Connor K D
Obstet Gynecol. 1985 Jul;66(1):59-62.
One hundred and three women who developed acute chorioamnionitis at 37 weeks' gestation or beyond were studied retrospectively. Clinical findings included fever (99.2%), fetal (82%) and maternal (19.4%) tachycardia, uterine tenderness (16.5%), and foul-smelling amniotic fluid (8.7%). Three of the 46 women who underwent cesarean section subsequently required addition of a second or third antibiotic for serious pelvic infection, whereas two had a subcutaneous wound infection requiring open drainage. Importantly, between zero and ten hours of the diagnosis of chorioamnionitis, a critical time interval where delivery impacted on neonatal infectious morbidity was not identified. Additionally, in the initial 24 hours after rupture of the fetal membranes there was no association between fetal, neonatal, or maternal complications versus duration of membrane rupture. These data suggest that immediate operative delivery of term gestations complicated by acute chorioamnionitis will not reduce neonatal morbidity.
对103例在妊娠37周及以后发生急性绒毛膜羊膜炎的女性进行了回顾性研究。临床症状包括发热（99.2%）、胎儿心动过速（82%）和母体心动过速（19.4%）、子宫压痛（16.5%）以及羊水有异味（8.7%）。46例行剖宫产的女性中，有3例随后因严重盆腔感染需要加用第二种或第三种抗生素，而有2例发生皮下伤口感染需要切开引流。重要的是，在绒毛膜羊膜炎诊断后的0至10小时之间，未发现分娩对新生儿感染性发病率有影响的关键时间间隔。此外，在胎膜破裂后的最初24小时内，胎儿、新生儿或母体并发症与胎膜破裂持续时间之间没有关联。这些数据表明，对于并发急性绒毛膜羊膜炎的足月妊娠立即进行手术分娩并不能降低新生儿发病率。
