Zanella P, Bogana G, Ciullo R, Zambon A, Serena A, Albertin M A
Dipartimento di Scienze Ginecologiche e della Riproduzione Umana, Università degli Studi di Padova, Italy.
Minerva Pediatr. 2010 Jun;62(3 Suppl 1):151-3.
Chorioamnionitis (CA) is defined as an infection that can affect amniotic fluid, placenta and uterus. The chorioamnionitis is present in 10-40% of cases of maternal peripartum fever and in 50% of preterm labor. Diagnosis is based on the presence of maternal fever (>38 degrees C) at least 2 of these conditions: maternal leukocytosis (> 15,000 cells/mmc), maternal tachycardia, fetal tachycardia, stained or foul smelling amniotic fluid, uterine tenderness. Obstetric risk factors include nulliparity, presence of stained amniotic fluid, the excessive duration of labor, the presence of pathogens in the genital tract (eg, Gonorrhea, GBS, EC), and the frequency of digital vaginal examinations. In suspicion of CA membranes and placenta are usually sent for histological examination performance, but the diagnosis of CS is not always confirmed by histological or microbiological exams. Early administration of broad-spectrum antibiotic therapy reduces both maternal and neonatal morbidity. The standard treatment by the administration of ampicillin and gentamicin have been shown to be safe and effective. Common maternal complications include bacteremia to septic shock, cesarean section, uterine atony with hemorrhage, pelvic abscess, maternal coagulopathy, thromboembolism and wound infections. The risk of neonatal sepsis, low seizures, low Apgar score at 5 minutes increased in the newborn. Cardiotocographic fetal monitoring should be continued during labor in cases of suspected chorioamnionitis with recourse to caesarean section as soon as signs of severe fetal distress.
绒毛膜羊膜炎(CA)被定义为一种可影响羊水、胎盘和子宫的感染。绒毛膜羊膜炎在10% - 40%的产妇围产期发热病例以及50%的早产病例中存在。诊断基于产妇出现以下至少两种情况:发热(>38摄氏度)、白细胞增多(>15,000个细胞/mmc)、心动过速、胎儿心动过速、羊水有染色或有异味、子宫压痛。产科危险因素包括初产、羊水有染色、产程过长、生殖道存在病原体(如淋病、B族链球菌、大肠杆菌)以及阴道指检频率。怀疑有CA时,胎膜和胎盘通常会送去进行组织学检查,但CA的诊断并非总能通过组织学或微生物学检查得到证实。早期给予广谱抗生素治疗可降低母婴发病率。使用氨苄西林和庆大霉素进行标准治疗已被证明是安全有效的。常见的产妇并发症包括菌血症至感染性休克、剖宫产、子宫收缩乏力伴出血、盆腔脓肿、产妇凝血功能障碍、血栓栓塞和伤口感染。新生儿败血症、低惊厥、5分钟时阿氏评分低的风险在新生儿中增加。在怀疑有绒毛膜羊膜炎的情况下,产程中应持续进行胎心监护,一旦出现严重胎儿窘迫迹象应立即进行剖宫产。