Chen Yi-Ran, Yang Xiao-Fan, Ding Xiao-Jie, Luo Ying, Kuai Le, Li Bin, Zhou Mi, Luo Yue, Fei Xiao-Ya
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Institute of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Arch Dermatol Res. 2025 Mar 20;317(1):608. doi: 10.1007/s00403-025-03983-9.
Eczema is a chronic, recurrent dermatosis with the skin repeated inflammation, itching, red and swollen. Such experience often take a physical and mental double burden on patients and their caregivers and family member. At present, the existing treatment methods have different limitations. In China, Kangfuxin liquid has been clinically used to treat eczema, and has shown good therapeutic effect. In order to conduct a more comprehensive analysis of clinical data and bring more references for clinicians and experts, this paper adopted a systematic review and meta-analysis to evaluate the effectiveness of Kangfuxin liquid in the treatment of eczema. We conducted a search in several databases, including EMBASE, PubMed, and the Cochrane Library, to identify suitable randomized controlled trials (RCTs). Following this, we gathered data from the RCTs which compared conventional therapies to Kangfuxin liquid alone or in combination with conventional therapies. We utilized RevMan 5.4 software to compute 95% confidence intervals (CIs) and risk ratios (RRs), and to carry out the meta-analysis. 17 meta-analyses involving 1725 patients were included. A meta-analysis showed that standalone Kangfuxin liquid therapy significantly improved the overall effective rate compared to nonglucocorticoid ointment therapy (Kangfuxin liquid vs nonglucocorticoid ointment: RR, 1.24; 95% CI, 1.09-1.42; P = 0.001). The total effective rate for standalone Kangfuxin liquid therapy was consistent with that of glucocorticoid ointment therapy (Kangfuxin liquid vs glucocorticoid ointment: RR, 1.09; 95% CI, 0.88-1.36; P = 0.41). In addition, the results were significantly improved when Kangfuxin liquid combined with conventional western medicine (Kangfuxin liquid + conventional Western medicine vs conventional Western medicine: RR, 1.12; 95% CI, 1.03-1.22; P = 0.009). Kangfuxin liquid can effectively treat eczema. However, further scale-up, involving more rigorous, precise, and inclusive meta-analyses are needed to make a significant difference in the treatment of eczema.
湿疹是一种慢性复发性皮肤病，皮肤反复出现炎症、瘙痒、红肿。这种情况常常给患者及其护理人员和家庭成员带来身心双重负担。目前，现有的治疗方法存在不同程度的局限性。在中国，康复新液已被临床用于治疗湿疹，并显示出良好的治疗效果。为了对临床数据进行更全面的分析，为临床医生和专家提供更多参考，本文采用系统评价和荟萃分析来评估康复新液治疗湿疹的有效性。我们在多个数据库中进行了检索，包括EMBASE、PubMed和Cochrane图书馆，以识别合适的随机对照试验（RCT）。在此之后，我们从将传统疗法与单独使用康复新液或与传统疗法联合使用的RCT中收集数据。我们使用RevMan 5.4软件计算95%置信区间（CI）和风险比（RR），并进行荟萃分析。纳入了涉及1725例患者的17项荟萃分析。一项荟萃分析表明，与非糖皮质激素软膏治疗相比，单独使用康复新液治疗显著提高了总有效率（康复新液与非糖皮质激素软膏：RR，1.24；95%CI，1.09 - 1.42；P = 0.001）。单独使用康复新液治疗的总有效率与糖皮质激素软膏治疗一致（康复新液与糖皮质激素软膏：RR，1.09；95%CI，0.88 - 1.36；P = 0.41）。此外，康复新液与传统西药联合使用时效果显著改善（康复新液 + 传统西药与传统西药：RR，1.12；95%CI，1.03 - 1.22；P = 0.009）。康复新液能有效治疗湿疹。然而，需要进一步扩大规模，进行更严谨、精确和全面的荟萃分析，才能在湿疹治疗上取得显著差异。
