Marini-Rapoport Orlee, Bhowmik Moumita, Patil Sarita U
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, USA.
Food Allergy Center, Massachusetts General Hospital, Boston, MA, USA.
Curr Allergy Asthma Rep. 2025 Mar 20;25(1):19. doi: 10.1007/s11882-025-01200-1.
As an ex-vivo test of allergic effector cell activation, basophil activation testing (BAT) to allergen enables quantification of the in-vivo IgE-mediated allergic response. BAT thus holds promise in the diagnosis and monitoring of peanut and tree nut allergies. Recent systematic analyses and expert recommendations support a role for BAT in the diagnosis of peanut and tree nut allergy.
Diagnostic cut-offs for BAT in peanut and tree nut allergy have been identified. Consistently, BAT can discriminate with high sensitivity and specificity between allergy and tolerance when measured against oral food challenges. Furthermore, the utilization of BAT has can increase the sensitivity and specificity of peanut allergy and tree nut allergy diagnosis, both alone and in conjunction with specific IgE testing and skin prick testing. BAT is a promising tool in the diagnosis of peanut and tree nut allergy.
作为过敏性效应细胞活化的体外试验，针对变应原的嗜碱性粒细胞活化试验（BAT）能够对体内IgE介导的过敏反应进行定量。因此，BAT在花生和坚果过敏的诊断及监测方面具有前景。近期的系统分析和专家建议支持BAT在花生和坚果过敏诊断中的作用。
已确定花生和坚果过敏中BAT的诊断临界值。一致的是，与口服食物激发试验相比，BAT能够以高灵敏度和特异性区分过敏与耐受。此外，BAT的应用无论是单独使用还是与特异性IgE检测及皮肤点刺试验联合使用，都能提高花生过敏和坚果过敏诊断的灵敏度和特异性。BAT是花生和坚果过敏诊断中一种很有前景的工具。
