Vo Jacqueline B, Brown Derek W, Buller Ian D, Shing Jaimie Z, Synnott Naoise, Jones Rena R, Landi Maria Teresa, Huang Wen-Yi, Machiela Mitchell J, Berrington De Gonzalez Amy, Nolan Timiya S, Kraft Peter, Williams Faustine, Freedman Neal D
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, U.S.A.
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, U.S.A.
J Natl Cancer Inst. 2025 Mar 20. doi: 10.1093/jnci/djaf066.
Self-identified race and ethnicity (SIRE) and genetic ancestry (GA) are potentially associated with disparities in health outcomes; however, independent effects of SIRE and GA on mortality in cancer survivors including when adjusting for multiple risk factors are understudied. Among 23,445 cancer survivors in the Prostate, Lung, Colorectal, and Ovarian Screening Trial, SIRE was associated with mortality among prostate, colorectal, lung, ovarian, and breast cancer survivors; GA was associated with mortality among prostate, colorectal, and breast cancer survivors. Associations were strong when adjusting for age at cancer diagnosis, sex, and tumor characteristics, but attenuated when adjusting for individual-level factors and population-level socioeconomic status. For example, mortality risk was higher among Black vs White prostate cancer survivors and African GA vs European GA, but associations were attenuated after multilevel adjustment. Results suggest SIRE and GA do not solely reflect biologic variation; rather, social factors may drive mortality differences by SIRE and GA.
自我认定的种族和族裔（SIRE）以及基因血统（GA）可能与健康结果的差异相关；然而，SIRE和GA对癌症幸存者死亡率的独立影响，包括在调整多个风险因素时的影响，尚未得到充分研究。在前列腺、肺、结肠直肠和卵巢癌筛查试验的23445名癌症幸存者中，SIRE与前列腺癌、结肠直肠癌、肺癌、卵巢癌和乳腺癌幸存者的死亡率相关；GA与前列腺癌、结肠直肠癌和乳腺癌幸存者的死亡率相关。在调整癌症诊断时的年龄、性别和肿瘤特征后，相关性很强，但在调整个体层面因素和人群层面社会经济地位后减弱。例如，黑人与白人前列腺癌幸存者以及非洲基因血统与欧洲基因血统相比，死亡风险更高，但在多水平调整后相关性减弱。结果表明，SIRE和GA并不 solely 反映生物学变异；相反，社会因素可能通过SIRE和GA导致死亡率差异。
原文中“solely”未翻译完整，推测可能是“仅仅”之意，因原文表述不太准确，整体译文尽量忠实原文呈现。
