Bettariga Francesco, Taaffe Dennis R, Borsati Anita, Avancini Alice, Pilotto Sara, Lazzarini Stefano G, Lopez Pedro, Maestroni Luca, Crainich Umberto, Campbell John P, Clay Timothy D, Galvão Daniel A, Newton Robert U
Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Australia.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
J Natl Cancer Inst. 2025 Mar 20. doi: 10.1093/jnci/djaf062.
Despite advances in breast cancer treatment, recurrence remains common and contributes to higher mortality risk. Among the potential mechanisms, inflammation plays a key role in recurrence by promoting tumor progression. Exercise provides a wide array of health benefits and may reduce inflammation, potentially reducing mortality risk. However, the effects of exercise, including mode (ie, resistance training [RT], aerobic training [AT], and combined RT and AT) and program duration, on inflammatory biomarkers in breast cancer survivors remain to be elucidated.
A systematic search was undertaken in PubMed, CINAHL, Embase, SPORTDiscus and CENTRAL in August 2024. Randomized controlled trials examining the effects of exercise on IL-1β, IL-6, IL-8, IL-10, TNF-α, and CRP were included. A random-effects meta-analysis was undertaken to quantify the magnitude of change.
Twenty-two studies were included (n = 968). Exercise induced small to large significant reductions in IL-6 (SMD = -0.85; 95% CI = -1.68 to -0.02; p = .05) and TNF-α (SMD = -0.40; 95% CI = -0.81 to 0.01; p = .05) and a trend for a decrease in CRP. When stratifying by exercise mode, trends toward reduction in IL-6 and TNF-α were observed for combined exercise, whilst changes were not generally affected by exercise program duration.
Exercise, especially combined RT and AT, can reduce pro-inflammatory biomarkers, and may be a suitable strategy to reduce inflammation in breast cancer survivors. However, further research is needed to investigate the effects of exercise mode and program duration on markers of inflammation in this survivor group.
尽管乳腺癌治疗取得了进展，但复发仍然很常见，并导致更高的死亡风险。在潜在机制中，炎症通过促进肿瘤进展在复发中起关键作用。运动具有广泛的健康益处，可能会减轻炎症，从而潜在地降低死亡风险。然而，运动的效果，包括运动模式（即抗阻训练[RT]、有氧训练[AT]以及RT与AT相结合）和运动计划持续时间，对乳腺癌幸存者炎症生物标志物的影响仍有待阐明。
2024年8月在PubMed、CINAHL、Embase、SPORTDiscus和CENTRAL进行了系统检索。纳入了研究运动对白细胞介素-1β、白细胞介素-6、白细胞介素-8、白细胞介素-10、肿瘤坏死因子-α和C反应蛋白影响的随机对照试验。进行随机效应荟萃分析以量化变化幅度。
纳入了22项研究（n = 968）。运动使白细胞介素-6（标准化均数差[SMD]= -0.85；95%置信区间[CI]= -1.68至-0.02；p = 0.05）和肿瘤坏死因子-α（SMD = -0.40；95% CI = -0.81至0.01；p = 0.05）有显著降低，降低幅度从小到大都有，并且C反应蛋白有下降趋势。按运动模式分层时，联合运动有白细胞介素-6和肿瘤坏死因子-α降低的趋势，而变化一般不受运动计划持续时间的影响。
运动，尤其是RT与AT相结合，可降低促炎生物标志物水平，可能是减轻乳腺癌幸存者炎症的合适策略。然而，需要进一步研究来调查运动模式和运动计划持续时间对该幸存者群体炎症标志物的影响。
