Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba'i University, Tehran, Iran.
School of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States; University Hospital and School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Cytokine. 2022 Jan;149:155712. doi: 10.1016/j.cyto.2021.155712. Epub 2021 Oct 10.
Despite several studies on the effects of exercise training on inflammatory biomarkers in patients with breast cancer, no earlier study has systematically summarized their findings. Current systematic review and meta-analysis has been done on earlier clinical trials in this topic.
Relevant studies published up to August 2021 were searched through PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar using predefined keywords. Studies that examined the effect of exercise training on inflammatory biomarkers in adult women with breast cancer were included.
A total of 18 studies were included. Combining 11 effect sizes, exercise training significantly reduced CRP level (WMD: -0.55; 95% CI: -1.10, -0.01). However, it had no significant influence on serum TNF-α (WMD: -0.40; 95% CI: -1.30, 0.50) and IL-6 concentrations (WMD: -0.05, 95% CI: -0.53, 0.43) in 8 and 15 studies, respectively. Pooling 7 effect sizes, we failed to find significant changes in IL-8 following exercise training (WMD: -0.65, 95% CI: -1.57, 0.28). Moreover, we reached no significant findings for serum levels of INF-ɣ (WMD: -2.66, 95% CI: -7.67, 2.36), IL-1β (WMD: 0.03, 95% CI: -0.26, 0.21), and IL-10 (WMD: -0.70, 95% CI: -2.92, 1.52). Based on subgroup analyses, best findings were reached in long-term intervention and after concurrent training.
Chronic inflammation is hypothesized to be associated with breast cancer development. We found significant reduction in CRP level following exercise training, which was more considerable after concurrent aerobic and resistance training and in long-term intervention. No significant changes were seen in serum levels of TNF-α, IL-6, IL-8, IL-10, INF-ɣ, IL-1β following exercise training. Further studies are needed to find more details.
尽管有几项关于运动训练对乳腺癌患者炎症生物标志物影响的研究，但此前尚无研究对其结果进行系统总结。目前针对这一主题进行了早期临床试验的系统综述和荟萃分析。
通过 PubMed、MEDLINE、SCOPUS、EMBASE 和 Google Scholar 使用预定义的关键词搜索了截至 2021 年 8 月发表的相关研究。纳入了研究运动训练对成年女性乳腺癌患者炎症生物标志物影响的研究。
共纳入 18 项研究。综合 11 项效应量的结果，运动训练显著降低 CRP 水平（WMD：-0.55；95%CI：-1.10，-0.01）。然而，在 8 项和 15 项研究中，运动训练对血清 TNF-α（WMD：-0.40；95%CI：-1.30，0.50）和 IL-6 浓度（WMD：-0.05，95%CI：-0.53，0.43）无显著影响。综合 7 项效应量的结果，我们未发现运动训练后 IL-8 有显著变化（WMD：-0.65，95%CI：-1.57，0.28）。此外，我们未发现血清 INF-ɣ（WMD：-2.66，95%CI：-7.67，2.36）、IL-1β（WMD：0.03，95%CI：-0.26，0.21）和 IL-10（WMD：-0.70，95%CI：-2.92，1.52）水平有显著变化。基于亚组分析，在长期干预和同时进行有氧和抗阻训练时，可获得最佳结果。
慢性炎症被认为与乳腺癌的发展有关。我们发现运动训练后 CRP 水平显著降低，在同时进行有氧和抗阻训练以及长期干预时更为显著。运动训练后血清 TNF-α、IL-6、IL-8、IL-10、INF-ɣ、IL-1β 水平无显著变化。需要进一步研究以发现更多细节。
