Lachkar Salim, Boualaoui Imad, Ibrahimi Ahmed, Hamada Syrine, El Sayegh Hachem, Nouini Yassine
Department of Urology A, Ibn Sina University Hospital, Rabat, Morocco.
Department of Urology A, Ibn Sina University Hospital, Rabat, Morocco.
Int J Surg Case Rep. 2025 Apr;129:111181. doi: 10.1016/j.ijscr.2025.111181. Epub 2025 Mar 18.
Epidermoid cysts are benign, keratin-filled lesions that rarely occur in the genital region. Diagnosis is primarily clinical, but histopathological examination is essential for confirmation. This case highlights a rare occurrence of an epidermoid cyst on the penis, emphasizing clinical features, diagnostic approach, and treatment outcomes.
A 35-year-old male presented with a non-tender, firm, well-circumscribed lesion measuring 2.5 cm × 1.8 cm located on the middle third of the left lateral aspect of the penis. Over eight months, the mass grew, causing pruritus, sexual discomfort, and self-image concerns, without pain or infection. Histopathological analysis confirmed the diagnosis of an epidermoid cyst, with stratified squamous epithelium and keratin-filled cystic spaces.
Although rare in the genital area, epidermoid cysts must be considered in the differential diagnosis of penile lesions. Clinical presentation, including a well-defined, mobile mass, is suggestive of the condition. Histopathological features, such as a cyst lined with squamous epithelium and keratin, are key to distinguishing it from other conditions like squamous cell carcinoma. Surgical excision with a margin is the treatment of choice, and recurrence is uncommon when performed adequately.
Epidermoid cysts of the penis are benign lesions with a favorable prognosis following surgical excision. This case demonstrates the importance of accurate diagnosis and management to avoid misdiagnosis and ensure successful treatment outcomes. The patient showed no recurrence at the 6-month follow-up.
表皮样囊肿是良性的、充满角蛋白的病变，很少发生于生殖器区域。诊断主要依靠临床，但组织病理学检查对于确诊至关重要。本病例突出了阴茎上罕见的表皮样囊肿的发生情况，强调了临床特征、诊断方法及治疗结果。
一名35岁男性患者，阴茎左侧面中三分之一处出现一个大小为2.5厘米×1.8厘米的无痛性、质地坚硬、边界清晰的病变。在八个月的时间里，肿物逐渐增大，引起瘙痒、性不适及自我形象方面的担忧，但无疼痛或感染症状。组织病理学分析确诊为表皮样囊肿，可见分层鳞状上皮及充满角蛋白的囊性间隙。
尽管表皮样囊肿在生殖器区域罕见，但在阴茎病变的鉴别诊断中必须予以考虑。临床表现，包括边界清晰、可活动的肿物，提示为此病。组织病理学特征，如内衬鳞状上皮及角蛋白的囊肿，是将其与鳞状细胞癌等其他疾病相鉴别的关键。带边缘的手术切除是首选治疗方法，若操作得当，复发并不常见。
阴茎表皮样囊肿是良性病变，手术切除后预后良好。本病例表明准确诊断和管理对于避免误诊及确保治疗成功的重要性。患者在6个月的随访中未出现复发。
