Karreman Matthia A, Venkataramani Varun
Neurology Clinic and European Center for Neurooncology (EZN), University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Neurology Clinic and European Center for Neurooncology (EZN), University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Neuron. 2025 Mar 19;113(6):795-797. doi: 10.1016/j.neuron.2025.02.020.
Primary brain tumors induce neuronal hyperexcitability, leading to epileptic seizures. In this issue of Neuron, Goldberg et al. demonstrate genetic, structural, and functional alterations to excitatory tumor-associated neurons and how mTOR inhibition rapidly reverses these changes in a mouse model.
原发性脑肿瘤会诱发神经元过度兴奋，导致癫痫发作。在本期《神经元》杂志中，戈德堡等人展示了兴奋性肿瘤相关神经元的基因、结构和功能改变，以及在小鼠模型中mTOR抑制如何迅速逆转这些变化。
