Luo Yiming, Yuan Ye, Liu Dan, Peng Haoxin, Shen Lin, Chen Yang
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing, China.
Early Drug Development Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing, China.
Trends Cancer. 2025 Jun;11(6):540-559. doi: 10.1016/j.trecan.2025.02.007. Epub 2025 Mar 19.
The B7-H family of immune checkpoint molecules is a crucial component of the immune regulatory network for tumors, offering new opportunities to modulate the tumor microenvironment (TME). The B7-H family - which includes B7-H2 (inducible T cell costimulatory ligand, ICOSL), B7-H3, B7-H4, B7-H5 (V-domain immunoglobulin suppressor of T cell activation, VISTA), B7-H6, and B7-H7 (HHLA2) - is known for its diverse roles in regulating innate and adaptive immunity. These molecules can exhibit co-stimulatory or co-inhibitory effects on T cells, influencing processes such as T cell activation, differentiation, and effector functions, and they are involved in the recruitment and polarization of various immune cells. This review explores the structural characteristics, receptor-ligand interactions, and signaling pathways associated with each B7-H family member. We also discuss the family's impact on tumor immunity and potential therapeutic strategies.
免疫检查点分子B7-H家族是肿瘤免疫调节网络的关键组成部分，为调节肿瘤微环境（TME）提供了新的机遇。B7-H家族包括B7-H2（诱导性T细胞共刺激配体，ICOSL）、B7-H3、B7-H4、B7-H5（T细胞活化V结构域免疫球蛋白抑制因子，VISTA）、B7-H6和B7-H7（HHLA2），以其在调节固有免疫和适应性免疫中的多种作用而闻名。这些分子可对T细胞表现出共刺激或共抑制作用，影响T细胞活化、分化和效应功能等过程，并参与各种免疫细胞的募集和极化。本综述探讨了与每个B7-H家族成员相关的结构特征、受体-配体相互作用和信号通路。我们还讨论了该家族对肿瘤免疫的影响以及潜在的治疗策略。
