Altaş Uğur, Taşar Sevinç, Başdoğan Nurbanu, Alkaya Halil, Çevik Seda, Altaş Zeynep M, Özkars Mehmet Yaşar
Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, Türkiye.
Department of Paediatric Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Umraniye, Istanbul, Türkiye.
Postepy Dermatol Alergol. 2025 Feb;42(1):105-109. doi: 10.5114/ada.2025.147855. Epub 2025 Feb 20.
An impaired skin barrier has been reported in allergic diseases.
In this study, we aimed to evaluate dermis thickness in children with house dust allergy without skin symptoms.
This cross-sectional study included children aged 4-18 years with asthma and/or allergic rhinitis. Participants were divided into three groups: healthy controls ( = 50), patients sensitized to house dust mites ( = 60), and patients with negative house dust mite tests ( = 48). The thickness of the dermis layers of the skin was measured at the cubital fossa using an ultrasound.
The median age and gender distribution were similar across the house dust mite-positive and -negative groups and the healthy control group. There was no significant difference between the groups in terms of dermis thickness ( = 0.053). Absolute eosinophils and eosinophil percentage were significantly negatively correlated with dermis ( < 0.05). There was no significant correlation between total IgE, house dust mite specific IgE and skin test values and skin thickness ( > 0.05).
The findings of this study highlight the impact of house dust mite sensitization on skin thickness, offering potential contributions to the management and treatment strategies of allergic diseases.
据报道，过敏性疾病患者存在皮肤屏障受损的情况。
在本研究中，我们旨在评估无皮肤症状的屋尘过敏儿童的真皮厚度。
这项横断面研究纳入了4至18岁患有哮喘和/或过敏性鼻炎的儿童。参与者被分为三组：健康对照组（n = 50）、对屋尘螨致敏的患者（n = 60）和屋尘螨检测阴性的患者（n = 48）。使用超声在肘窝处测量皮肤真皮层的厚度。
屋尘螨阳性组、阴性组和健康对照组的年龄中位数和性别分布相似。各组之间的真皮厚度无显著差异（P = 0.053）。绝对嗜酸性粒细胞和嗜酸性粒细胞百分比与真皮显著负相关（P < 0.05）。总IgE、屋尘螨特异性IgE和皮肤试验值与皮肤厚度之间无显著相关性（P > 0.05）。
本研究结果突出了屋尘螨致敏对皮肤厚度的影响，为过敏性疾病的管理和治疗策略提供了潜在贡献。
