Rosenfield Lana, Tsoulis Michael William, Milio Kirolos, Schnittke Meghan, Kim Harold
Division of Clinical Immunology and Allergy, Department of Medicine Michael D. DeGroote School of Medicine, McMaster University, Hamilton, ON Canada.
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON Canada.
Allergy Asthma Clin Immunol. 2017 Jan 19;13:5. doi: 10.1186/s13223-017-0177-x. eCollection 2017.
Shrimp and house dust mite (HDM) allergies are common in Canadians. Often, both of these allergies occur in the same patient. This may be due to homology of tropomyosin or other potentially shared proteins. The aim of our study was to assess the frequency of house dust mite sensitization in a shrimp allergic Canadian population.
We undertook a retrospective chart review of shrimp allergic patients at an outpatient allergy clinic in Kitchener, Ontario, Canada. Our primary endpoint was to assess for presence of HDM sensitization in this population. Patients were categorized into approximate quartiles. We assessed the severity of the shrimp reactions, correlated shrimp skin test size to HDM skin test size, and measured the proportion of patients with atopic symptoms.
We identified 95 shrimp allergic patients who were tested for house dust mite. 86 (90.5%) of these patients had a positive skin test to HDM. Patients with a shrimp skin test ≥5 mm were 5.31 times (95% CI, 1.55-18.14; p = 0.008) more likely to exhibit a dust mite skin test ≥5 mm than patients with a shrimp skin test <5 mm. The odds of a patient with a shrimp skin test between 10 and 18 mm having a larger HDM skin test were 3.93 times (95% CI 1.03-14.98, p = 0.045) the odds for a patient with a shrimp skin test size between 3 and 4 mm. We did not find a correlation between shrimp skin test size and shrimp reaction symptom grade (p = 0.301).
In our Canadian patients, we found a large majority of shrimp allergic patients to be sensitized to HDM. We found that patients with a large skin test to shrimp were more likely to have a large skin test to HDM compared to those patients with a small skin test to shrimp. We did not find a correlation between shrimp skin test size and shrimp reaction symptom severity. Most of these patients had symptoms of rhinitis and/or asthma that may have been caused by house dust mite allergy.
虾类和屋尘螨（HDM）过敏在加拿大人中很常见。通常，这两种过敏会出现在同一患者身上。这可能是由于原肌球蛋白的同源性或其他潜在的共享蛋白质。我们研究的目的是评估加拿大虾类过敏人群中屋尘螨致敏的频率。
我们对加拿大安大略省基奇纳一家门诊过敏诊所的虾类过敏患者进行了回顾性病历审查。我们的主要终点是评估该人群中HDM致敏的情况。患者被分为大致四分位数。我们评估了虾类反应的严重程度，将虾类皮肤试验大小与HDM皮肤试验大小进行关联，并测量了有特应性症状患者的比例。
我们确定了95名接受屋尘螨检测的虾类过敏患者。其中86名（90.5%）患者对HDM皮肤试验呈阳性。虾类皮肤试验≥5mm的患者出现HDM皮肤试验≥5mm的可能性是虾类皮肤试验<5mm患者的5.31倍（95%CI，1.55 - 18.14；p = 0.008）。虾类皮肤试验在10至18mm之间的患者HDM皮肤试验更大的几率是虾类皮肤试验大小在3至4mm之间患者的3.93倍（95%CI 1.03 - 14.98，p = 0.045）。我们未发现虾类皮肤试验大小与虾类反应症状分级之间存在相关性（p = 0.301）。
在我们的加拿大患者中，我们发现绝大多数虾类过敏患者对HDM致敏。我们发现，与虾类皮肤试验较小的患者相比，虾类皮肤试验较大的患者更有可能对HDM皮肤试验呈阳性。我们未发现虾类皮肤试验大小与虾类反应症状严重程度之间存在相关性。这些患者中的大多数有鼻炎和/或哮喘症状，可能是由屋尘螨过敏引起的。
