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用于伤口愈合的电纺载药纳米纤维:综述

Electrospun Medicated Nanofibers for Wound Healing: Review.

作者信息

Liu Xinkuan, Xu Haixia, Zhang Mingxin, Yu Deng-Guang

机构信息

School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Shanghai Engineering Technology Research Center for High-Performance Medical Device Materials, Shanghai 200093, China.

出版信息

Membranes (Basel). 2021 Oct 9;11(10):770. doi: 10.3390/membranes11100770.

Abstract

With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers' attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

摘要

随着全球对伤口护理和治疗的需求不断增加,传统敷料因其有限的抗菌性能和其他缺陷已无法满足现有市场的需求。静电纺丝技术作为一种简单且通用的制造方法,已吸引了越来越多研究人员的关注。静电纺丝纳米纤维膜具有与细胞外基质(ECM)相似的独特结构和生物学功能,被认为是一种先进的伤口敷料。它们在封装和递送促进伤口愈合的活性物质方面具有巨大潜力。本文首先讨论了伤口敷料的常见类型,然后总结了静电纺丝纤维制备技术的发展。最后,总结了用于静电纺丝伤口敷料的聚合物和常见生物活性物质,并讨论了便携式静电纺丝设备。此外,还提出了未来的研究需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/8537333/c7298f933f32/membranes-11-00770-g001.jpg

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