Environment and Health, Department of Public Health and Primary Care, KU Leuven, ON5 Herestraat 49, Box 952, 3000, Leuven, Belgium.
Arch Toxicol. 2023 Jun;97(6):1453-1517. doi: 10.1007/s00204-023-03481-9. Epub 2023 Apr 26.
With increasing numbers of cancer cases, the use of antineoplastic agents is expected to rise. This will be accompanied by an increase in occupational exposure, which can cause unwanted health effects in workers. Our aim was to give an overview of genotoxic and epigenetic effects after occupational exposure to antineoplastic agents and to assess the concentration-effect relation. Four databases were searched for papers investigating genotoxic and/or epigenetic effects of occupational exposure to antineoplastic agents. Out of the 245 retrieved papers, 62 were included in this review. In this systematic literature review, we confirmed that exposure of healthcare workers to antineoplastic agents can lead to genotoxic damage. However, we observed a lack of data on exposure as well as genotoxic and epigenetic effects in workers other than healthcare workers. Furthermore, gaps in the current knowledge regarding the potential epigenetic effects caused by antineoplastic drug exposure and regarding the link between internal antineoplastic drug concentration and genotoxic and epigenetic effects after occupational exposure to antineoplastic agents were identified, offering a first step for future research.
随着癌症病例的不断增加，预计抗肿瘤药物的使用将会增加。这将伴随着职业暴露的增加，这可能会对工人的健康造成不良影响。我们的目的是概述职业接触抗肿瘤药物后的遗传毒性和表观遗传效应，并评估浓度-效应关系。四个数据库被用来搜索调查职业接触抗肿瘤药物的遗传毒性和/或表观遗传效应的论文。在检索到的 245 篇论文中，有 62 篇被纳入本综述。在这个系统的文献综述中，我们证实了接触抗肿瘤药物的医护人员可能会导致遗传毒性损伤。然而，我们观察到缺乏关于除医护人员以外的工人的暴露以及遗传毒性和表观遗传效应的数据。此外，还发现了当前关于抗肿瘤药物暴露引起的潜在表观遗传效应以及内部抗肿瘤药物浓度与职业接触抗肿瘤药物后的遗传毒性和表观遗传效应之间联系的知识空白，为未来的研究提供了第一步。
