Butt Aayesha, Tariq Swaleha, Kanwal Fatima
Department Family Medicine, Dow University of Health Sciences, Karachi, Sindh, Pakistan.
Department Family Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan.
J Family Med Prim Care. 2025 Feb;14(2):549-555. doi: 10.4103/jfmpc.jfmpc_905_24. Epub 2025 Feb 21.
Dietary sodium and renin-angiotensin system activity are pivotal in causing primary hypertension. Vitamin D levels inversely relate to the renin-angiotensin system. Our study investigates the association between vitamin D fluctuations and blood pressure control in hypertensive patients undergoing general health checkups.
A cross-sectional study enrolled participants with essential hypertension from family medicine clinics at the Aga Khan University Hospital, Karachi, coming for a general health checkup. Data including demographics, Vitamin D levels, blood pressure, factors associated with hypertension, and vitamin D deficiency were noted and analyzed using SPSS 20. Post-stratification chi-square test was applied to check for the association between different categorical variables.
In a study of 203 hypertensive subjects (mean age: 58.07 ± 11 years, 56.2% male, 63.5% Urdu speaking), 41.4% were smokers, and 63.1% had other comorbidities along with hypertension. Significant vitamin D deficiency was observed in 81.8%, with 55.7% exhibiting uncontrolled blood pressure. Vitamin D levels were significantly associated with blood pressure changes, sun exposure, gender, physical activity, and salt restriction. Smoking and obesity are also correlated with blood pressure changes.
Pakistan faces significant hypertension and vitamin D deficiency burdens. Our study found a potential link between varying vitamin D levels and blood pressure fluctuations in hypertensive patients, warranting further research.
饮食中的钠和肾素-血管紧张素系统活性在原发性高血压的发生中起关键作用。维生素D水平与肾素-血管紧张素系统呈负相关。我们的研究调查了接受常规健康检查的高血压患者中维生素D波动与血压控制之间的关联。
一项横断面研究纳入了来自卡拉奇阿迦汗大学医院家庭医学诊所前来进行常规健康检查的原发性高血压患者。记录了包括人口统计学、维生素D水平、血压、高血压相关因素以及维生素D缺乏等数据，并使用SPSS 20进行分析。应用分层后卡方检验来检查不同分类变量之间的关联。
在一项对203名高血压受试者（平均年龄：58.07±11岁，56.2%为男性，63.5%说乌尔都语）的研究中，41.4%为吸烟者，63.1%除高血压外还患有其他合并症。81.8%的人存在显著的维生素D缺乏，55.7%的人血压未得到控制。维生素D水平与血压变化、阳光照射、性别、身体活动和限盐显著相关。吸烟和肥胖也与血压变化相关。
巴基斯坦面临着严重的高血压和维生素D缺乏负担。我们的研究发现高血压患者维生素D水平变化与血压波动之间存在潜在联系，值得进一步研究。
