Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Belfast Health and Social Care Trust, Belfast, UK.
BMC Endocr Disord. 2020 Jun 5;20(1):81. doi: 10.1186/s12902-020-00562-z.
Obesity and diabetes are related conditions, the prevalence of which has increased globally in recent years. These conditions have been linked to hypertension and vitamin D deficiency though the nature of the relationship remains unclear and is likely to vary between identifiable groups and specific contexts. The aim of this paper is to examine the relationships between obesity, type 2 diabetes, hypertension and vitamin D, among Saudis citizens aged 15 and over.
Self-reported and measured data were taken from the 2013 Saudi Health Interview Survey and analysed using a series of seemingly unrelated bivariate probit regression (SURBVP) analyses. Sensitivity analyses were undertaken in which the selection and specification of covariates and outcomes were varied.
In the main analysis data on 957 women and 1127 men were analysed. Differences were evident between men and women in the prevalence of type 2 diabetes, obesity, central obesity, hypertension and vitamin D deficiency. While men were more likely to experience diabetes and hypertension, women were more likely to experience obesity, central obesity and vitamin D deficiency. In multivariable analyses obesity and age were found to significantly predict hypertension risk in women; central obesity to predict diabetes risk in men and women, as well as hypertension risk in men. Vitamin D was not found to predict diabetes risk nor hypertension risk in either sex. Milk consumption and sun exposure were found to predict vitamin D deficiency in women but not men. While there was evidence of unobserved heterogeneity in models predicting diabetes and hypertension, there was no evidence of unobserved heterogeneity between these and those predicting vitamin D deficiency. Results did not materially change over a range of sensitivity analyses.
While there is strong evidence of distinct patterns in the relationship between diabetes, hypertension and obesity among men and women in Saudi Arabia and in the risk of vitamin D deficiency, we found no evidence of a relationship between vitamin D levels and risk of either diabetes or hypertension.
肥胖和糖尿病是相关的病症,近年来在全球范围内的发病率都有所上升。这些病症与高血压和维生素 D 缺乏有关,但两者之间的关系性质尚不清楚,而且可能因可识别的群体和特定环境而有所不同。本文旨在研究沙特 15 岁及以上公民中肥胖、2 型糖尿病、高血压和维生素 D 之间的关系。
本研究使用 2013 年沙特健康访谈调查中的自我报告和测量数据,通过一系列似乎不相关的双变量概率回归(SURBVP)分析进行分析。进行了敏感性分析,其中改变了协变量和结果的选择和指定。
在主要分析中,对 957 名女性和 1127 名男性的数据进行了分析。2 型糖尿病、肥胖、中心性肥胖、高血压和维生素 D 缺乏的患病率在男性和女性之间存在差异。虽然男性更易患糖尿病和高血压,但女性更易患肥胖、中心性肥胖和维生素 D 缺乏。在多变量分析中,肥胖和年龄被发现显著预测女性患高血压的风险;中心性肥胖预测男性和女性患糖尿病的风险,以及男性患高血压的风险。维生素 D 未被发现预测男性和女性患糖尿病或高血压的风险。牛奶消费和阳光照射被发现可预测女性的维生素 D 缺乏,但不能预测男性。虽然在预测糖尿病和高血压的模型中存在未观察到的异质性的证据,但在预测维生素 D 缺乏的模型中没有发现这种异质性。在一系列敏感性分析中,结果没有实质性变化。
虽然有强有力的证据表明,在沙特阿拉伯的男性和女性中,糖尿病、高血压和肥胖之间存在明显的关系模式,以及维生素 D 缺乏的风险,但我们没有发现维生素 D 水平与糖尿病或高血压风险之间存在关系。