Smith R L, Van Hartesveldt C
Pharmacol Biochem Behav. 1985 May;22(5):689-93. doi: 10.1016/0091-3057(85)90514-3.
The effects of ovariectomy, sham ovariectomy, and estradiol benzoate replacement on unilateral intrastriatal dopamine-induced postural deviation were studied in rats. Animals were tested prior to surgery, and at both two and seven days after surgery. Relative to the pre-surgery test, ovariectomized rats greatly increased this behavioral response two days after surgery while sham ovariectomy resulted in no significant change. Estradiol benzoate treatment in ovariectomized animals not only prevented this increase but significantly suppressed it at both two and seven days after surgery relative to pre-surgery levels. Thus, removal of endogenous estrogen in female rats resulted in an acute increase in a striatal DA-mediated behavior which could be prevented by hormone replacement. These results are consistent with the hypothesis that estrogen suppresses some striatal DA-mediated behaviors.
研究了卵巢切除术、假卵巢切除术和苯甲酸雌二醇替代对大鼠单侧纹状体内多巴胺诱导的姿势偏差的影响。在手术前以及手术后两天和七天对动物进行测试。相对于手术前测试，卵巢切除的大鼠在手术后两天大大增加了这种行为反应，而假卵巢切除术则没有导致显著变化。对卵巢切除的动物进行苯甲酸雌二醇治疗，不仅阻止了这种增加，而且相对于手术前水平，在手术后两天和七天均显著抑制了这种增加。因此，雌性大鼠体内内源性雌激素的去除导致纹状体多巴胺介导的行为急性增加，而激素替代可以预防这种增加。这些结果与雌激素抑制某些纹状体多巴胺介导的行为这一假设一致。
