雌二醇先抑制然后增强尾状核内多巴胺诱导的对侧偏斜。

Estradiol suppresses then enhances intracaudate dopamine-induced contralateral deviation.

作者信息

Joyce J N, Smith R L, van Hartesveldt C

出版信息

Eur J Pharmacol. 1982 Jun 16;81(1):117-22. doi: 10.1016/0014-2999(82)90608-2.

Abstract

The effects of estradiol on the amount of contralateral postural deviation elicited by unilateral intracaudate injection of dopamine (DA) were tested 2 days and 6 days after hormone treatment. DA (25 micrograms/0.25 microliter) or a control vehicle solution (VH, 0.25 microliter) was injected unilaterally into the dorsal anterior caudate-putamen of intact male rats and postural deviation was measured. Then, rats were given estradiol benzoate (EB, 50 micrograms/100 g body wt per 0.05 ml) or the vehicle, peanut oil (OIL, 0.05 ml/100 g body wt) once. At 2 days and 6 days after EB or OIL treatment, the rats were again administered DA or VH intrastriatally and the amount of contralateral postural deviation was measured. At 2 days after EB treatment the response to intrastriatal DA was significantly decreased, but by 6 days it was significantly increased; OIL had no effect. Thus, the behavioral effects of estrogen are time-dependent and may affect the postsynaptic response to DA in the striatum.

摘要

在激素治疗2天和6天后，测试了雌二醇对单侧尾状核内注射多巴胺（DA）引起的对侧姿势偏差量的影响。将DA（25微克/0.25微升）或对照溶媒溶液（VH，0.25微升）单侧注射到完整雄性大鼠的背侧前尾状核-壳核中，并测量姿势偏差。然后，给大鼠单次注射苯甲酸雌二醇（EB，50微克/100克体重每0.05毫升）或溶媒花生油（OIL，0.05毫升/100克体重）。在EB或OIL治疗2天和6天后，再次向大鼠纹状体内注射DA或VH，并测量对侧姿势偏差量。在EB治疗2天后，对纹状体内DA的反应显著降低，但到6天时显著增加；OIL没有影响。因此，雌激素的行为效应具有时间依赖性，可能会影响纹状体中对DA的突触后反应。