Joyce J N, Montero E, Van Hartesveldt C
Pharmacol Biochem Behav. 1984 Nov;21(5):791-800. doi: 10.1016/s0091-3057(84)80021-0.
Several behaviors produced by intrastriatal injection of dopamine (DA) and amphetamine (AMPHET) in ovariectomized (OVX) rats were each modulated by estradiol benzoate (EB) in different ways. Contralateral postural deviation and rotation, induced by unilateral injections of DA and AMPHET into the dorsal striatum, were differentially suppressed with EB treatment. Postural deviation was suppressed by 1/2 hour after a single treatment with EB (2 micrograms). In contrast, suppression of contralateral rotation required two treatments with EB separated by an interval of 48 or 96 hours, and the suppression was observed at 24 hours after the last treatment with EB. However, treatment with the antiestrogen CI-628 blocked the suppressive effects of EB on either behavior. The enhanced locomotion produced by bilateral injections of AMPHET into the ventral striatum was not suppressed with EB. In fact, AMPHET-enhanced locomotor activity decreased after a 3-week absence of estradiol as a consequence of OVX, and was returned to early OVX levels by EB. Therefore, postural deviation, rotation, and locomotor activity are mediated by different underlying mechanisms in the striatum and are affected differently by estradiol.
在去卵巢（OVX）大鼠中，纹状体内注射多巴胺（DA）和苯丙胺（AMPHET）所产生的几种行为，均受到苯甲酸雌二醇（EB）的不同方式调节。向背侧纹状体单侧注射DA和AMPHET所诱导的对侧姿势偏差和旋转，经EB处理后受到不同程度的抑制。单次给予EB（2微克）处理后1/2小时，姿势偏差受到抑制。相比之下，抑制对侧旋转需要两次EB处理，间隔48或96小时，且在最后一次EB处理后24小时观察到抑制效果。然而，抗雌激素CI - 628的处理阻断了EB对这两种行为的抑制作用。向腹侧纹状体双侧注射AMPHET所产生的增强运动不受EB抑制。事实上，由于OVX导致雌二醇缺失3周后，AMPHET增强的运动活性降低，而EB使其恢复到OVX早期水平。因此，姿势偏差、旋转和运动活性在纹状体中由不同的潜在机制介导，且受雌二醇的影响也不同。
