Bushman Yevheniia, Mirikar Duhita A, Truman Andrew W
Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Cell Chem Biol. 2025 Mar 20;32(3):381-383. doi: 10.1016/j.chembiol.2025.02.005.
Molecular chaperones like Hsp70s are key players in protein quality control (PQC), capable of eliminating toxic intracellular condensates. In this issue of Cell Chemical Biology, Zhang et al. present a computational approach to design novel J-domain protein (JDP) constructs that bind to Hsp70 and enhance its chaperone activity.
像热休克蛋白70（Hsp70s）这样的分子伴侣是蛋白质质量控制（PQC）的关键参与者，能够消除有毒的细胞内凝聚物。在本期《细胞化学生物学》中，张等人提出了一种计算方法，用于设计与Hsp70结合并增强其伴侣活性的新型J结构域蛋白（JDP）构建体。
