Qian Jialei, Ren Shengyuan, Ren Tianning, Shi Renke, Qiao Liang, Kang Jing
School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, China.
The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, China.
Neurochem Res. 2025 Sep 5;50(5):287. doi: 10.1007/s11064-025-04532-6.
Astrocytes, the most abundant and functionally diverse glial cell type in the brain, play a crucial role in maintaining cellular homeostasis and promoting neuronal survival. Autophagy is the process of transferring senescent, denatured, or damaged proteins and organelles from cells to lysosomes for degradation. However, recent research on autophagy in the central nervous system has focused on neurons. In this paper, we reviewed the latest findings on astrocyte autophagy and its mechanisms in regulating neurodegenerative disorders. It influences the pathological processes of Alzheimer's disease, Parkinson's disease, Huntington's disease, and other synucleinopathies (including dementia with Lewy bodies and Parkinson's disease dementia) by regulating oxidative stress and inflammatory responses, as well as aberrant protein aggregation and folding. Furthermore, we listed medications that can prevent or treat neurodegenerative disorders by modulating astrocyte autophagy pathways, providing new insights into preventive and therapeutic strategies for neurodegenerative diseases.
星形胶质细胞是大脑中数量最多、功能多样的神经胶质细胞类型，在维持细胞内稳态和促进神经元存活方面发挥着关键作用。自噬是将衰老、变性或受损的蛋白质和细胞器从细胞转运到溶酶体进行降解的过程。然而，最近关于中枢神经系统自噬的研究主要集中在神经元上。在本文中，我们综述了星形胶质细胞自噬及其调节神经退行性疾病机制的最新研究成果。它通过调节氧化应激和炎症反应以及异常的蛋白质聚集和折叠，影响阿尔茨海默病、帕金森病、亨廷顿病和其他突触核蛋白病（包括路易体痴呆和帕金森病痴呆）的病理过程。此外，我们列出了可通过调节星形胶质细胞自噬途径预防或治疗神经退行性疾病的药物，为神经退行性疾病的预防和治疗策略提供了新的见解。
