Sohail Muhammad Umer, Khan Taimor Mohammed, Sajid Maryam, Imran Zahra, Salim Hussain, Waqas Saad Ahmed, Mactaggart Sebastian, Ahmed Raheel
Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Department of Medicine, Northumbria Healthcare NHS Foundation Trust, North Shields, UK.
Diabetes Res Clin Pract. 2025 May;223:112112. doi: 10.1016/j.diabres.2025.112112. Epub 2025 Mar 19.
The co-occurrence of diabetes mellitus (DM) and atrial fibrillation (AF) poses growing health risks in the United States (U.S.), with diabetes patients having a 34 % higher risk of AF. This study examines trends in DM and AF related mortality among individuals aged ≥ 25 years in the U.S. from 1999 to 2020. Data from the CDC WONDER database were analyzed calculating age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC), stratified by age, sex, race/ethnicity, urbanization, and region. Between 1999 and 2020, 419,036 deaths were recorded among U.S. adults (≥25 years) with comorbid AF and DM. The AAMR rose from 4.83 in 1999 to 15.91 in 2020, with an APC increase of 15.01 from 2018 to 2020. Older adults (≥65) had higher AAMRs than younger adults (25-64). Men (11.23) had higher rates than women (7.16). NH American Indian/Alaskan Natives (9.54) and Whites (9.16) had the highest AAMRs, while NH Asian/Pacific Islanders (6.04) had the lowest. Non-metropolitan areas (10.32) exceeded metropolitan areas (8.53). The Western U.S. (9.87) had the highest regional AAMR. Rising DM and AF-related deaths highlight a growing burden, particularly in men, NH American Indian/Alaskan Natives and Whites, and rural populations, necessitating targeted interventions.
在美国，糖尿病（DM）和心房颤动（AF）同时出现带来的健康风险日益增加，糖尿病患者患AF的风险要高34%。本研究调查了1999年至2020年美国25岁及以上人群中与DM和AF相关的死亡率趋势。分析了疾病控制与预防中心（CDC）的WONDER数据库中的数据，计算了每10万人的年龄调整死亡率（AAMR）和年度百分比变化（APC），并按年龄、性别、种族/族裔、城市化程度和地区进行分层。1999年至2020年期间，美国患有AF和DM合并症的成年人（≥25岁）中有419,036人死亡。AAMR从1999年的4.83上升到2020年的15.91，2018年至2020年的APC增长了15.01。老年人（≥65岁）的AAMR高于年轻人（25 - 64岁）。男性（11.23）的死亡率高于女性（7.16）。美国本土印第安人/阿拉斯加原住民（9.54）和白人（9.16）的AAMR最高，而美国本土亚裔/太平洋岛民（6.04）的AAMR最低。非大都市地区（10.32）超过了大都市地区（8.53）。美国西部（9.87）的地区AAMR最高。与DM和AF相关的死亡人数不断上升，凸显了日益加重的负担，尤其是在男性、美国本土印第安人/阿拉斯加原住民和白人以及农村人口中，因此需要有针对性的干预措施。
