Rubin L A, Urowitz M B, Gladman D D
Q J Med. 1985 Apr;55(216):87-98.
A review of 51 patients who died while enrolled in a long-term prospective study of systemic lupus erythematosus (SLE) revealed that active SLE may persist or reappear late in the course of the disease. Vascular events, especially atherosclerotic coronary artery disease, occurred frequently. Moderate to severe atherosclerosis was seen in patients who had died of any cause after a prolonged duration of the disease and often contributed significantly to death. Diffuse proliferative glomerulonephritis, CNS lupus and major infections were indications of poor prognosis particularly early in its course.
对51例在系统性红斑狼疮（SLE）长期前瞻性研究中死亡的患者进行回顾发现，活动性SLE可能在疾病后期持续存在或再次出现。血管事件，尤其是动脉粥样硬化性冠状动脉疾病，频繁发生。在病程较长后因任何原因死亡的患者中可见中度至重度动脉粥样硬化，且常是死亡的重要原因。弥漫性增殖性肾小球肾炎、中枢神经系统狼疮和严重感染是预后不良的指征，尤其是在疾病早期。
