Liou Jyun-You, Maciver M Bruce, Sleigh Jamie W
Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Br J Anaesth. 2025 Apr;134(4):900-902. doi: 10.1016/j.bja.2024.12.013. Epub 2025 Feb 21.
The neural mechanisms underlying burst suppression during anaesthesia remain poorly understood. A recent study in the British Journal of Anaesthesia used calcium imaging to examine neuronal activity driving burst suppression in both cortical and subcortical structures. The results reveal diverse involvement of cortical excitatory neurones in burst suppression, while distinct interneurone subtypes play varied roles. Parvalbumin neurones in particular are key in modulating these rhythms. These insights will inform anaesthetic management of patients with neurological vulnerabilities.
麻醉期间爆发抑制的神经机制仍未得到充分理解。最近发表在《英国麻醉学杂志》上的一项研究利用钙成像技术来检测驱动皮质和皮质下结构中爆发抑制的神经元活动。结果显示，皮质兴奋性神经元在爆发抑制中有着不同程度的参与，而不同的中间神经元亚型发挥着各异的作用。尤其是小白蛋白神经元在调节这些节律方面起着关键作用。这些见解将为有神经功能脆弱性的患者的麻醉管理提供依据。
