肠道神经元和免疫细胞塑造抗蠕虫免疫力。

Enteric neurons and immune cells shape anti-helminth immunity.

作者信息

Kerner Zachary, Kodra Albana L, Mucida Daniel

机构信息

Laboratory of Mucosal Immunology, Rockefeller University, New York, NY, USA.

Laboratory of Mucosal Immunology, Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, Rockefeller University, New York, NY, USA.

出版信息

Trends Parasitol. 2025 Apr;41(4):267-268. doi: 10.1016/j.pt.2025.03.002. Epub 2025 Mar 20.

DOI:10.1016/j.pt.2025.03.002

PMID:40118699

Abstract

Wang et al. recently reported that during helminth infection, innate lymphoid cell (ILC)-derived IL-13 is sensed by gut neurons, which in turn secretes CGRP to inhibit ILC2 proliferation and anti-helminth responses. Hence, this study demonstrates a bidirectional crosstalk between enteric neurons and immune cells that regulates type-2 immunity.

摘要

王等人最近报道，在蠕虫感染期间，肠道神经元可感知由固有淋巴细胞（ILC）产生的白细胞介素-13（IL-13），进而分泌降钙素基因相关肽（CGRP）以抑制ILC2增殖和抗蠕虫反应。因此，本研究证明了肠神经元与免疫细胞之间存在双向串扰，可调节2型免疫。