Sábato Sofía, Benet Susana, Rogers Angela J, Murray Thomas A, Skeans Melissa, Mothe Beatriz, Paredes Roger, Mourad Ahmad, Kiweewa Francis, Kamel Dena, Jain Mamta K, Lutaakome Joseph, Nalubega Mary Grace, Sebudde Nicholus, Mylonakis Eleftherios, Braun Dominique L, Hatlen Timothy, Kimuli Ivan, Kitko Cissy, Mugerwa Henry, Kitonsa Jonathan, Kim Kami, Tien Phyllis C, Highbarger Jeroen, McCormack Ashley L, Sanchez Adriana, Murray Daniel D, Babiker Abdel G, Davey Victoria J, Files D Clark, Gelijns Annetine C, Higgs Elizabeth S, Kan Virginia L, Matthews Gail V, Pett Sarah L, Lane H Clifford, Reilly Cavan, Goodman Anna L, Lundgren Jens D, Moltó José
Fundació Lluita Contra Les Infeccions, Badalona, Spain.
Department of Infectious Diseases, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Sci Rep. 2025 Mar 22;15(1):9882. doi: 10.1038/s41598-025-92742-x.
The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individuals to receive either immediate or deferred vaccination, with one or two doses of mRNA SARS-CoV-2 vaccines. We measured binding and neutralizing antibodies against SARS-CoV-2 at enrollment and longitudinally. Median (IQR) time from SARS-CoV-2 infection to first vaccination was 68 (53-75) days in the immediate group, and 151 (137-173) days in the deferred group. At week 48, timing or number of vaccine doses did not influence the change in antibody levels relative to baseline. Adherence to the assigned vaccine regimen was lower in the deferred group, particularly in participants receiving two doses. Although the study ultimately lacked adequate power to draw firm conclusions, these results suggest possible benefits of prompt vaccination after recovery from COVID-19.
既往感染过新冠病毒的人群接种新冠病毒疫苗后，免疫原性和效力受到的影响可能因接种时间和剂量不同而有所差异。VATICO研究将66名住院康复的新冠病毒感染者随机分为两组，分别立即接种或延迟接种一剂或两剂mRNA新冠病毒疫苗。我们在入组时及随访期间检测了针对新冠病毒的结合抗体和中和抗体。立即接种组从新冠病毒感染到首次接种的中位（四分位间距）时间为68（53 - 75）天，延迟接种组为151（137 - 173）天。在第48周时，接种时间或剂量并未影响抗体水平相对于基线的变化。延迟接种组对指定疫苗接种方案的依从性较低，尤其是接受两剂疫苗的参与者。尽管该研究最终缺乏足够的效力得出确凿结论，但这些结果表明新冠病毒康复后及时接种疫苗可能有益。
