Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
J Infect Dis. 2022 Nov 28;226(11):1903-1908. doi: 10.1093/infdis/jiac321.
In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).
在这项基于人群的 7538 名成年人队列研究中，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗接种后测量的免疫球蛋白 G（IgG）、免疫球蛋白 A（IgA）和免疫球蛋白 M（IgM）（IgG/A/M）抗刺突抗体滴度可预测对突破性 SARS-CoV-2 感染的保护作用。通过调整影响 SARS-CoV-2 暴露风险的因素（包括家庭拥挤、使用公共交通工具和室内公共场所的访问），可显著提高对 SARS-CoV-2 感染的预测效果。抗刺突 IgG/A/M 滴度与中和抗体滴度呈正相关（rs=0.80[95%置信区间，0.72-0.86]；P<0.001），与 S 肽刺激的干扰素-γ浓度呈正相关（rs=0.31[0.13-0.47]；P<0.001）。
