Marotte J H, Frottier J, Cazalet G, Lord G, Blanchard J P, Guillamon J L
Rev Chir Orthop Reparatrice Appar Mot. 1985;71(2):79-86.
In a previous paper the authors studied the role of aerobio-contamination in the rate of post-operative infections. In the present study, the results of 1,172 total hip prostheses performed between 1979/1982 with prophylactic antibiotics were compared with those obtained in 811 cases performed before 1979 without antibiotics. In the 1979/1982 series, there was 0,5 p. 100 of post-operative infection and in the pre- 1979 series, 3,3 p. 100. During the two periods the peri-operative environment was identical and the surgical technique was the same. The rate of infection in more than 8,000 other surgical procedures performed in the same hospital remained the same. The use of prophylactic antibiotics appears to be a valid approach. They should be used only in high-risk procedures to avoid the selective production of resistant organisms.
在之前的一篇论文中，作者研究了空气生物污染在术后感染发生率中的作用。在本研究中，将1979年至1982年间使用预防性抗生素进行的1172例全髋关节置换术的结果与1979年之前未使用抗生素的811例病例的结果进行了比较。在1979/1982系列中，术后感染率为0.5%，而在1979年之前的系列中为3.3%。在这两个时期，围手术期环境相同，手术技术也相同。在同一家医院进行的8000多例其他外科手术的感染率保持不变。预防性抗生素的使用似乎是一种有效的方法。它们应仅用于高风险手术，以避免耐药菌的选择性产生。
