Collins Amanda C, Gallagher Michael R, Calafiore Camryn, Jordan D Gage, Winer E Samuel
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States.
Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, United States; Department of Psychology, Mississippi State University, Mississippi State, MS, United States.
J Affect Disord. 2025 Jul 1;380:17-25. doi: 10.1016/j.jad.2025.03.074. Epub 2025 Mar 20.
Anxiety and depression are highly comorbid with each other, warranting a need to better understand transdiagnostic mechanisms. Anhedonia has been hypothesized as a transdiagnostic mechanism but has often been investigated as a unidimensional factor. Thus, the current study examined how anticipatory and consummatory anhedonia, including how they interact with anxiety, predict next-week depression. Participants (N = 101) completed weekly assessments of anxiety, depression, and anhedonia. Using an iterative approach, we constructed four models to investigate independent and interactive effects of prior-week anxiety and anhedonia on next-week depression, as well as the effects of depression and anhedonia on anxiety. Our results indicate that anticipatory anhedonia is associated with next-week depression, and the association between anxiety and depression is greater when anticipatory anhedonia is high. The current findings provide insight into the transdiagnostic nature of anticipatory anhedonia between anxiety and depression. Future work should investigate how these associations may unfold over shorter time periods.
焦虑和抑郁常常相互伴发，因此有必要更好地理解跨诊断机制。快感缺乏被假定为一种跨诊断机制，但通常被作为一个单维因素进行研究。因此，本研究考察了预期性快感缺乏和体验性快感缺乏，包括它们如何与焦虑相互作用，对下周的抑郁进行预测。参与者（N = 101）每周完成对焦虑、抑郁和快感缺乏的评估。我们采用迭代法构建了四个模型，以研究前一周的焦虑和快感缺乏对下周抑郁的独立和交互作用，以及抑郁和快感缺乏对焦虑的影响。我们的结果表明，预期性快感缺乏与下周的抑郁相关，当预期性快感缺乏程度较高时，焦虑和抑郁之间的关联更强。当前的研究结果为预期性快感缺乏在焦虑和抑郁之间的跨诊断性质提供了见解。未来的研究应探讨这些关联在更短时间内是如何发展的。
