Neuroglia in aging.

Aging is associated with morphologic and functional decline of the brain active milieu and, in particular, of the neuroglia, which compromises homeostatic support and neuroprotection. Astrocytes in aging undergo complex and region specific changes, manifested by morphologic atrophy and widespread functional asthenia. Aging leads to mitochondrial malfunction and reduced protein/lipid ratio in human astrocytes. Oligodendrocyte lineage cells are the most affected cells by the aging process, which limits myelinating capacity, thus leading to a substantial reduction in the white matter and deficient brain connectome. Finally, microglia undergo a morphologic functional dystrophy in the aged human brain which curtails brain defenses and increases brain vulnerability to neuropathology and especially to age-dependent neurodegenerative disorders. Lifestyle modifications, such as enriched environment, physical exercise, and healthy dieting, boost neuroglial support, thus improving cognitive longevity.