Lu Guanghan, Liu Jingxuan, Wei Xiang, Yan Jiuqi, Sun Jian, Dong Wenwen, Zhao Liang, Qiu Chang, Luo Bei, Zhang Wenbin
Department of Functional Neurosurgery, Nanjing Brain Hospital, Nanjing, Jiang Su, People's Republic of China.
Infect Drug Resist. 2025 Mar 17;18:1485-1490. doi: 10.2147/IDR.S497124. eCollection 2025.
Deep Brain Stimulation (DBS) is an established treatment option for movement disorders such as Parkinson's disease and dystonia, so more and more patients (over 160,000 patients till 2019) worldwide have undergone DBS for a variety of neurological and non-neurological conditions, with numbers increasing each year. This case series primarily discusses a very rare complication following DBS surgery -- brain abscess.
We administered vancomycin and metronidazole to patients who developed brain abscesses after undergoing DBS surgery based on previous literature. After treatment, the abscess lesions and infection symptoms completely resolved, resulting in a good therapeutic outcome without the removal of the DBS system.
In previous studies, similar cases always involved surgical intervention to drain the pus while also removing the DBS system; however, in our cases, the patient did not have the DBS system removed and achieved a good prognosis. To our knowledge, our two cases are among the few where a conservative treatment approach has been used for brain abscesses after DBS surgery.
脑深部电刺激术(DBS)是治疗帕金森病和肌张力障碍等运动障碍的既定治疗选择,因此全球越来越多的患者(截至2019年超过16万例)因各种神经和非神经疾病接受了DBS治疗,且数量逐年增加。本病例系列主要讨论DBS手术后一种非常罕见的并发症——脑脓肿。
根据既往文献,我们对DBS手术后发生脑脓肿的患者给予万古霉素和甲硝唑治疗。治疗后,脓肿病灶和感染症状完全消退,在未移除DBS系统的情况下取得了良好的治疗效果。
在以往的研究中,类似病例总是需要手术干预引流脓液,同时移除DBS系统;然而,在我们的病例中,患者未移除DBS系统且预后良好。据我们所知,我们的这两例是少数采用保守治疗方法治疗DBS术后脑脓肿的病例。