Zheng Lili, Lei Huifang, Tang Xiaoyi, Zheng Yuanyin, Wu Qiuzhen, Chen Peixuan, Chen Yanhong, Cai Liangzhi
Department of Gynecology, Mindong Hospital Affiliated to Fujian Medical University, Ningde, People's Republic of China.
Department of Laboratory, Mindong Hospital Affiliated to Fujian Medical University, Ningde, People's Republic of China.
Int J Womens Health. 2025 Mar 17;17:825-833. doi: 10.2147/IJWH.S497621. eCollection 2025.
To investigate the relationship between hepatic steatosis index (HSI) and endometrial cancer (EC) and its diagnostic value for EC.
A total of 114 patients with pathologically diagnosed EC in Mindong Hospital, Ningde City, Fujian Province from 2016 to 2022 were retrospectively included as the EC group. A total of 175 patients with pathologically confirmed benign endometrial lesions (endometrial polyps and uterine submucosal fibroids) in the same hospital during the same period were selected as the control group. Non-parametric test were used to compare the differences in HSI and non-alcoholic fatty liver disease (NAFLD) between the two groups, and the diagnostic value of HSI and NAFLD levels on EC was analysed. The cut-off point of continuous variables was determined by receiver operating characteristic (ROC) curve analysis. Logistic regression analysis was used to calculate odds ratios (ORs).
The results showed that compared with the control group, serum GGT, CA125, HDL-C and HSI were significantly increased in the EC group (P<0.05). 27.19% of the EC patients (31/114) and 12% of the control group (21/175) had NAFLD, and the difference between the two groups was statistically significant (P<0.05). The results of univariate logistic regression analysis showed that GGT, CA125, HDL-C, HSI and NAFLD were significantly correlated with the occurrence of EC (P<0.05). Further multivariate logistic regression analysis showed that CA125 and HSI elevation were independent risk factors for EC (P<0.05).
NAFLD is closely associated with EC, and elevated HSI is an independent risk factor for EC.
探讨肝脏脂肪变性指数（HSI）与子宫内膜癌（EC）的关系及其对EC的诊断价值。
回顾性纳入2016年至2022年在福建省宁德市闽东医院病理诊断为EC的114例患者作为EC组。同期在同一医院选取175例经病理证实为良性子宫内膜病变（子宫内膜息肉和子宫黏膜下肌瘤）的患者作为对照组。采用非参数检验比较两组HSI及非酒精性脂肪性肝病（NAFLD）的差异，并分析HSI和NAFLD水平对EC的诊断价值。连续变量的截断点通过受试者工作特征（ROC）曲线分析确定。采用逻辑回归分析计算比值比（OR）。
结果显示，与对照组相比，EC组血清γ-谷氨酰转移酶（GGT）、癌抗原125（CA125）、高密度脂蛋白胆固醇（HDL-C）和HSI显著升高（P<0.05）。27.19%的EC患者（31/114）和12%的对照组患者（21/175）患有NAFLD，两组差异有统计学意义（P<0.05）。单因素逻辑回归分析结果显示，GGT、CA125、HDL-C、HSI和NAFLD与EC的发生显著相关（P<0.05）。进一步多因素逻辑回归分析显示，CA125升高和HSI升高是EC的独立危险因素（P<0.05）。
NAFLD与EC密切相关，HSI升高是EC的独立危险因素。
