Lembas Agnieszka, Załęski Andrzej, Mikuła Tomasz, Kozłowska Joanna, Wiercińska-Drapało Alicja
Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, ul. Żwirki i Wigury 61, 02-091 Warsaw, Poland.
Hospital for Infectious Diseases in Warsaw, ul. Wolska 37, 01-201 Warsaw, Poland.
IJID Reg. 2025 Feb 13;14:100602. doi: 10.1016/j.ijregi.2025.100602. eCollection 2025 Mar.
This study aimed to analyze lipid profiles among people with HIV and observe changes in lipid parameters during 1 year of antiretroviral therapy (ART), with particular reference to immune parameters.
We analyzed adult newly diagnosed people with HIV (PWH) who started ART, continued uninterruptedly for 1 year and achieved complete viral suppression. Patients were not receiving lipid-lowering therapy. The cluster of differentiation (CD4) count, CD4:CD8 ratio, HIV type 1 viral load, and lipid profile were examined at HIV diagnosis and after 12 months of ART.
The study included 70 patients. Significant increases in total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol and decreases in triglyceride concentrations after 1 year of ART were observed. A baseline CD4 count <200/µl was associated with higher baseline LDL cholesterol ( = 0.036), and female sex with elevated total, LDL, and non-HDL cholesterol ( = 0.005; = 0.011; 0.008). Patients with baseline CD4 counts <200/µl had significantly higher total, LDL, and non-HDL cholesterol ( = 0.033; = 0.009; = 0.009) and triglyceride ( = 0.003) levels after 1 year of ART than patients with CD4 levels ≥200/µl.
Lipid parameters should be regularly assessed in all PWH receiving ART, especially in patients with baseline CD4 counts <200/µl.
本研究旨在分析HIV感染者的血脂谱，并观察抗逆转录病毒疗法（ART）1年内血脂参数的变化，尤其参考免疫参数。
我们分析了开始接受ART、持续不间断治疗1年且实现完全病毒抑制的成年新诊断HIV感染者（PWH）。患者未接受降脂治疗。在HIV诊断时及ART治疗12个月后检查分化簇（CD4）计数、CD4:CD8比值、1型HIV病毒载量和血脂谱。
该研究纳入了70名患者。观察到ART治疗1年后总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇显著升高，甘油三酯浓度降低。基线CD4计数<200/µl与较高的基线LDL胆固醇相关（P = 0.036），女性与总胆固醇、LDL胆固醇和非HDL胆固醇升高相关（P = 0.005；P = 0.011；P = 0.008）。基线CD4计数<200/µl的患者在ART治疗1年后的总胆固醇、LDL胆固醇和非HDL胆固醇（P = 0.033；P = 0.009；P = 0.009）以及甘油三酯（P = 0.003）水平显著高于CD4水平≥200/µl的患者。
所有接受ART的PWH都应定期评估血脂参数，尤其是基线CD4计数<200/µl的患者。
