Zeng Junjian, Liao Zhiqiang, Lin Aiqing, Zou Yu, Chen Yixun, Liu Zhonghua, Luo Hongqing, Zhou Zhidong
Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
J Pain Res. 2025 Mar 18;18:1313-1323. doi: 10.2147/JPR.S504303. eCollection 2025.
Poor pain control may lead to persistent physical discomfort and even reduced perceptual abilities. This research seeks to investigate the relationship between pain status and duration and sensory impairments.
This study used data on pain and sensory impairments from the National Health and Nutrition Examination Survey (NHANES) conducted from 2011 to 2014, including 8043 participants. Functional status of vision, hearing, smell, and taste was gathered using structured questionnaires. Logistic regression models were used to evaluate the association between pain status, duration, and the total number of sensory impairments and specific sensory deficits, while adjusting for key covariates such as age, gender, BMI, and socioeconomic status. Stratified analysis was performed to determine factors that might confound this relationship.
The multivariable-adjusted regression model showed that individuals with pain for 1 to 3 years had a 64% increased risk of sensory impairment compared to those without pain (OR 1.640, 95% CI 1.132-2.376, = 0.016), while those with pain for over 3 years had a 90.9% increased risk (OR 1.909, 95% CI 1.472-2.475, = 0.001). We also found a statistically significant association between pain duration of ≥ 1 year and visual impairment (OR 1.841, 95% CI 1.252-2.705, < 0.01). Furthermore, participants with pain duration > 3 years were significantly associated with olfactory impairment (OR 2.264, 95% CI 1.538-3.331, < 0.001) and taste impairment (OR 2.070, 95% CI 1.335-3.209, < 0.01). However, no statistically significant association was observed between pain duration and hearing impairment in any duration category.
The results of this study suggest that individuals with longer chronic pain duration are at higher risk of sensory impairments, particularly visual, olfactory, and taste impairments. Timely and effective pain management may help reduce the risk of long-term sensory impairments.
疼痛控制不佳可能导致持续的身体不适,甚至降低感知能力。本研究旨在调查疼痛状态、持续时间与感觉障碍之间的关系。
本研究使用了2011年至2014年美国国家健康与营养检查调查(NHANES)中有关疼痛和感觉障碍的数据,共纳入8043名参与者。通过结构化问卷收集视力、听力、嗅觉和味觉的功能状态信息。使用逻辑回归模型评估疼痛状态、持续时间与感觉障碍总数及特定感觉缺陷之间的关联,同时对年龄、性别、体重指数和社会经济地位等关键协变量进行调整。进行分层分析以确定可能混淆这种关系的因素。
多变量调整回归模型显示,疼痛1至3年的个体与无疼痛个体相比,感觉障碍风险增加64%(比值比[OR]1.640,95%置信区间[CI]1.132 - 2.376,P = 0.016),而疼痛超过3年的个体风险增加90.9%(OR 1.909,95% CI 1.472 - 2.475,P = 0.001)。我们还发现疼痛持续时间≥1年与视力障碍之间存在统计学显著关联(OR 1.841,95% CI 1.252 - 2.705,P < 0.01)。此外,疼痛持续时间>3年的参与者与嗅觉障碍(OR 2.264,95% CI 1.538 - 3.331,P < 0.001)和味觉障碍(OR 2.070,95% CI 1.335 - 3.209,P < 0.01)显著相关。然而,在任何持续时间类别中,均未观察到疼痛持续时间与听力障碍之间存在统计学显著关联。
本研究结果表明,慢性疼痛持续时间较长的个体感觉障碍风险较高,尤其是视力、嗅觉和味觉障碍。及时有效的疼痛管理可能有助于降低长期感觉障碍的风险。