Liu Yalu, Zhang Zhengpei, Guan Lina, Li Jie, Ge Xing, Wu Xiaochen, Liu Haiyang
The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou 221002, China.
Department of Ophthalmology, Xuzhou First People's Hospital, Xuzhou 221002, China.
Int J Pharm X. 2025 Feb 26;9:100325. doi: 10.1016/j.ijpx.2025.100325. eCollection 2025 Jun.
Corneal injury is a common ailment that, if not addressed promptly and efficiently, has the potential to result in significant visual impairment. This study investigates the therapeutic potential of a novel FU/PVP/Hes nanoparticle complex composed of fucoidan (FU), polyvinylpyrrolidone (PVP), and hesperitin (Hes) for corneal injury treatment. The FU/PVP/Hes nanoparticles were synthesized using a solvent evaporation method and characterized for their morphology, size distribution, biocompatibility, antioxidant activity, and anti-inflammatory capacity. The nanoparticles demonstrated excellent biocompatibility with low hemolysis rates and minimal cytotoxicity. They also exhibited potent antioxidant and anti-inflammatory properties, which were attributed to the enhanced solubility and bioavailability of Hes through nanoparticle formation. investigations employing a mouse model of corneal injury induced by alkali burns showed that the FU/PVP/Hes nanoparticles significantly promoted corneal epithelial healing, reduced corneal opacity, and suppressed the elevation of inflammatory cytokines. Histopathological analysis confirmed the nanoparticles' ability to facilitate corneal tissue repair. The study concludes that the FU/PVP/Hes nanoparticle complex is a promising therapeutic agent for corneal injury treatment due to its biocompatibility and multifaceted therapeutic effects.
角膜损伤是一种常见疾病，如果不能及时有效地处理，有可能导致严重的视力损害。本研究调查了一种由岩藻依聚糖（FU）、聚乙烯吡咯烷酮（PVP）和橙皮素（Hes）组成的新型FU/PVP/Hes纳米颗粒复合物在治疗角膜损伤方面的潜力。采用溶剂蒸发法合成了FU/PVP/Hes纳米颗粒，并对其形态、尺寸分布、生物相容性、抗氧化活性和抗炎能力进行了表征。纳米颗粒表现出优异的生物相容性，溶血率低且细胞毒性极小。它们还表现出强大的抗氧化和抗炎特性，这归因于通过形成纳米颗粒提高了橙皮素的溶解度和生物利用度。采用碱烧伤诱导的小鼠角膜损伤模型进行的研究表明，FU/PVP/Hes纳米颗粒显著促进角膜上皮愈合，降低角膜混浊度，并抑制炎性细胞因子的升高。组织病理学分析证实了纳米颗粒促进角膜组织修复的能力。该研究得出结论，由于其生物相容性和多方面的治疗效果，FU/PVP/Hes纳米颗粒复合物是一种有前景的角膜损伤治疗药物。
