Xu Xiaotong, Zhu Tong, Jing Changyou, Jiang Minjie, Fu Yunlai, Xie Fang, Meng Qinghua, Li Jianjun
Department of Oncology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Front Med (Lausanne). 2025 Mar 7;12:1423780. doi: 10.3389/fmed.2025.1423780. eCollection 2025.
Transjugular intrahepatic portosystemic shunt (TIPS) placement alleviates portal hypertension symptoms. Hepatic encephalopathy (HE) is a common complication of TIPS, impacting patient quality of life and the healthcare burden. Post-TIPS HE is associated with portosystemic shunting, elevated blood ammonia levels, and inflammation. Increasing attention has been given to the liver and intestinal circulation in recent years. An imbalance in intestinal microecology plays a role in the occurrence of HE and may be a new target for treatment. This review discusses the causes, diagnosis, and treatment strategies for post-TIPS HE and focuses on exploring treatment strategies and their relationships with the gut microbiota, suggesting an innovative approach to address this complication.
经颈静脉肝内门体分流术（TIPS）置放可缓解门静脉高压症状。肝性脑病（HE）是TIPS的常见并发症，影响患者生活质量及医疗负担。TIPS术后HE与门体分流、血氨水平升高及炎症相关。近年来，肝脏和肠道循环越来越受到关注。肠道微生态失衡在HE的发生中起作用，可能成为新的治疗靶点。本文综述了TIPS术后HE的病因、诊断及治疗策略，重点探讨治疗策略及其与肠道微生物群的关系，提出应对这一并发症的创新方法。
