用于诊断无焦痂型恙虫病的脑脊液第二代宏基因组测序
The second generation metagenomic sequencing of cerebrospinal fluid for diagnosis of non-eschar scrub typhus.
作者信息
Li Shujing, Zhang Sufang, Zhou Tao, Ge Zhe, Li Yi, Zhang JiYing, Zhu Yifei, Li Shaoying
机构信息
920 Hospital Clinical College, Kunming Medical University, 1168 Chunrong West Road, Chenggong District, Kunming City, Yunnan Province 650500, China.
Department of Respiratory and Critical Care Medicine, 920th Hospital of Joint Logistics Support Force PLA, Kunming No. 212, Daguan Road, Xishan District, Yunnan Province, 650500, China.
出版信息
Oxf Med Case Reports. 2025 Mar 20;2025(3):omae198. doi: 10.1093/omcr/omae198. eCollection 2025 Mar.
Tsutsugamushi disease, is an infectious disease transmitted by ticks and caused by the rickettsiella. It is characterized by eschar, fever, rash, and flu-like symptoms. However, diagnosing atypical cases without an eschar and with negative Weil-Felix test results poses a significant diagnostic challenge. This study presents a noteworthy case of non-eschar typhus which was effectively diagnosed using advanced next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) samples.
恙虫病是一种由蜱传播、立克次氏体引起的传染病。其特征为焦痂、发热、皮疹及流感样症状。然而，诊断无焦痂且外斐试验结果为阴性的非典型病例面临重大诊断挑战。本研究报告了一例值得关注的无焦痂型斑疹伤寒病例，该病例通过对脑脊液（CSF）样本进行先进的二代测序（mNGS）得以有效诊断。
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