Sochett E B, Pettifor J M, Moodley G, Pentopoulos M
S Afr Med J. 1985 Jun 29;67(26):1041-4.
The apparent decline over the last decade of vitamin D deficiency rickets among black infants in South Africa has suggested a significant improvement in their vitamin D status. Levels of serum 25-hydroxy-vitamin D, calcium, phosphorus and alkaline phosphatase, together with a radiograph of the left wrist, were obtained in 114 hospitalized black infants under the age of 2 years in order to establish the frequency of infants with or at risk of vitamin D deficiency. Mean 25-hydroxyvitamin D levels were found to be in the low normal range and showed no correlation with either age or season. Vitamin D stores were depleted in 7% and relatively deficient in 20,7% with suggestive radiological features of rickets in only 2 patients. The high prevalence of malnutrition and infection made a biochemical assessment of rickets impossible. The significance of these suboptimal vitamin D levels is uncertain, but the available literature would suggest that these infants are at increased risk of developing vitamin D deficiency rickets.
过去十年间，南非黑人婴儿中维生素D缺乏性佝偻病的发病率明显下降，这表明他们的维生素D状况有了显著改善。为确定维生素D缺乏或有缺乏风险的婴儿的发生率，对114名2岁以下住院黑人婴儿进行了血清25-羟维生素D、钙、磷和碱性磷酸酶水平检测，并拍摄了左手腕X光片。结果发现，平均25-羟维生素D水平处于低正常范围，且与年龄和季节均无相关性。7%的婴儿维生素D储备耗尽，20.7%相对缺乏，仅有2例患者有佝偻病的影像学特征。营养不良和感染的高发生率使得无法对佝偻病进行生化评估。这些次优维生素D水平的意义尚不确定，但现有文献表明，这些婴儿患维生素D缺乏性佝偻病的风险增加。
