Raghuramulu N, Reddy V
Arch Dis Child. 1980 Apr;55(4):285-7. doi: 10.1136/adc.55.4.285.
Serum levels of calcium, phosphorus, alkaline phosphatase, and 25 hydroxy-vitamin D (25-OH-D3) were measured in normal and malnourished children with and without rickets. Children with rickets had clinical, biochemical, and x-ray evidence of the disease; most of them were malnourished. 25-OH-D3 levels were lower than in normal children. After treatment with vitamin D their condition improved. 25-OH-D3 levels were also found to be reduced in malnourished children without rickets. These studies show that rickets is common in malnourished children. Inadequate exposure to sunlight appears to be the factor mainly responsible for the high incidence of the disease. In addition, malnutrition perhaps contributes to the development of rickets.
对患有和未患佝偻病的正常儿童及营养不良儿童的血清钙、磷、碱性磷酸酶和25羟维生素D（25-OH-D3）水平进行了测量。患有佝偻病的儿童有该疾病的临床、生化及X线证据；他们中的大多数营养不良。25-OH-D3水平低于正常儿童。经维生素D治疗后，他们的状况有所改善。在未患佝偻病的营养不良儿童中也发现25-OH-D3水平降低。这些研究表明，佝偻病在营养不良儿童中很常见。阳光照射不足似乎是该疾病高发病率的主要原因。此外，营养不良可能也促成了佝偻病的发生。
