Lundanes Julianne, Nes Vilde Fiske, Aakervik Oda, Ryan Liv, Hansson Patrik, Rokstad Anne Mari, Martins Catia, Nymo Siren
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Nord-Trøndelag Hospital Trust, Clinic of Surgery, Namsos Hospital, Namsos, Norway.
Curr Dev Nutr. 2025 Feb 20;9(3):104571. doi: 10.1016/j.cdnut.2025.104571. eCollection 2025 Mar.
Lipedema is considered an inflammation-related disease, and low-carbohydrate ketogenic diets may help reduce inflammation. However, no randomized controlled trials have investigated the effect of a low-carbohydrate ketogenic diet on inflammatory markers in females with lipedema.
To compare changes in inflammatory and fibrosis-associated markers after a low-energy low-carbohydrate diet (LCD) compared with a low-fat diet in females with lipedema, and to explore potential associations between changes in pain and changes in inflammatory and fibrosis-associated markers.
Females with lipedema and obesity were randomly assigned to either an LCD or low-fat diet (both 1200 kcal/d) for 8 weeks. Body composition [fat mass (FM) and fat-free mass] and the plasma concentrations of high-sensitivity C-reactive protein (hsCRP), cytokines, and fibrosis-associated markers were measured pre- and postintervention.
A total of 70 females were included (35/group) (mean age: 47.3 ± 10.9 y, BMI: 36.9 ± 4.9 kg/m). Both groups lost weight and FM (kg and %), with a greater reduction in the LCD group. A reduction in macrophage inflammatory protein-1ß, tumor necrosis factor-α, and hsCRP was seen in the LCD group only, despite no significant differences between groups. No associations were found between changes in pain and changes in cytokines and fibrosis-associated markers.
Changes in cytokines and fibrosis-associated markers did not differ between low-energy LCD and low-fat diets in females with lipedema, despite a beneficial profile in the LCD group. Inflammation does not seem to be involved in pain reduction following LCD in this patient group.
This trial was registered at clinicaltrials.gov as NCT04632810.
脂肪性水肿被认为是一种与炎症相关的疾病，低碳水化合物生酮饮食可能有助于减轻炎症。然而，尚无随机对照试验研究低碳水化合物生酮饮食对脂肪性水肿女性炎症标志物的影响。
比较低能量低碳水化合物饮食（LCD）与低脂饮食对脂肪性水肿女性炎症和纤维化相关标志物的影响，并探讨疼痛变化与炎症和纤维化相关标志物变化之间的潜在关联。
将患有脂肪性水肿和肥胖的女性随机分为LCD组或低脂饮食组（均为1200千卡/天），为期8周。在干预前后测量身体成分[脂肪量（FM）和去脂体重]以及高敏C反应蛋白（hsCRP）、细胞因子和纤维化相关标志物的血浆浓度。
共纳入70名女性（每组35名）（平均年龄：47.3±10.9岁，BMI：36.9±4.9千克/米²）。两组体重和FM均下降（千克和百分比），LCD组下降幅度更大。仅LCD组巨噬细胞炎性蛋白-1β、肿瘤坏死因子-α和hsCRP有所下降，尽管两组间无显著差异。疼痛变化与细胞因子和纤维化相关标志物变化之间未发现关联。
对于患有脂肪性水肿的女性，低能量LCD饮食和低脂饮食在细胞因子和纤维化相关标志物变化方面无差异，尽管LCD组有有益表现。在该患者群体中，炎症似乎与LCD饮食后疼痛减轻无关。
本试验在clinicaltrials.gov注册，注册号为NCT04632810。
