Shaaban Yasmine Maher, Badran Tamer Abdel Fattah
Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams Specialized Hospital, Cairo, 11588, Egypt.
Clin Ophthalmol. 2025 Mar 19;19:973-984. doi: 10.2147/OPTH.S509766. eCollection 2025.
To compare the effects of applied suction using microkeratome Laser-assisted in situ keratomileusis. (LASIK), femtosecond-laser in-situ keratomileusis (Fs-LASIK), and Small Incision Lenticule Extraction (Fe-SMILE) on the thickness of the Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Layer (GCL).
This study included 72 eyes divided into three groups, each with 24 eyes. Each group underwent one of three different procedures. Preoperatively, at one day, one week, and three months postoperatively, Spectral Domain Optical Coherence Tomography (SD-OCT) was used to evaluate the thickness of RNFL and GCL.
Preoperatively and at one day, one week, and three months postoperatively, the mean values for RNFL thickness in the LASIK group were 93.2 ± 3.2, 105.9 ± 3.8, 106.2 ± 3.3, and 93.3 ± 3.6 μm, respectively; for the Fs-LASIK group, they were 95.9 ± 3.1, 100.2 ± 3.3, 100.5 ± 3.3, and 96.1 ± 3.1 μm, respectively; and for the Fe-SMILE group, they were 95.6 ± 1.9, 99.8 ± 1.7, 100.2 ± 1.8, and 95.8 ± 1.9 μm, respectively. The mean values for GCL thickness in the LASIK group were 73.9 ± 4.7, 90.2 ± 2.8, 90.8 ± 2.2, and 74.8 ± 4.5 μm, respectively; for the Fs-LASIK group, they were 77.8 ± 4.2, 80.2 ± 3.7, 80.3 ± 3.7, and 77.8 ± 3.5 μm, respectively; and for the Fe-SMILE group, they were 77.0 ± 3.7, 79.8 ± 3.6, 80 ± 3.7, and 77.1 ± 3.6 μm, respectively.
All three procedures resulted in a transient increase in RNFL and GCL thicknesses. This increase was rapid, limited, transient, and reversible. It peaked for a week and returned to baseline by the end of this three-month study. At day one and day seven post-operatively, the Lasik group exhibited statistically significantly higher values than the Fs-Lasik and Fe-Smile groups.
比较使用微型角膜刀准分子原位角膜磨镶术（LASIK）、飞秒激光原位角膜磨镶术（Fs-LASIK）和小切口基质透镜切除术（Fe-SMILE）施加负压对视网膜神经纤维层（RNFL）和神经节细胞层（GCL）厚度的影响。
本研究纳入72只眼，分为三组，每组24只眼。每组接受三种不同手术中的一种。术前、术后1天、1周和3个月，使用光谱域光学相干断层扫描（SD-OCT）评估RNFL和GCL的厚度。
术前、术后1天、1周和3个月，LASIK组RNFL厚度的平均值分别为93.2±3.2、105.9±3.8、106.2±3.3和93.3±3.6μm；Fs-LASIK组分别为95.9±3.1、100.2±3.3、100 .5±3 . 和96.1±3.1μm；Fe-SMILE组分别为95.6±1.9、99.8±1.7、100.2±1.8和95.8±1.9μm。LASIK组GCL厚度的平均值分别为73.9±4.7、90.2±2.8、90.8±2.2和74.8±4.5μm；Fs-LASIK组分别为77.8±4.2、80.2±3.7、80.3±3.7和77.8±3.5μm；Fe-SMILE组分别为77.0±3.7、79.8±3.6、80±3.7和77.1±3.6μm。
所有三种手术均导致RNFL和GCL厚度短暂增加。这种增加迅速、有限、短暂且可逆。在术后1周达到峰值，并在本三个月研究结束时恢复至基线水平。术后第1天和第7天，LASIK组的值在统计学上显著高于Fs-LASIK组和Fe-SMILE组。
