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评论:是时候摒弃青少年期“精神病临床高危状态”(CHR-P)这一概念了吗?对弗里尔森等人《针对精神病临床高危儿童及青少年的预防性干预措施的疗效:干预研究的系统评价与荟萃分析》的评论

Commentary: Time to abandon the 'clinical high risk state for psychosis' (CHR-P) concept in adolescence? Commentary on Frearson et al. 'Efficacy of preventative interventions for children and adolescents at clinical high risk of psychosis: A systematic review and meta-analysis of intervention studies'.

作者信息

Tiffin Paul A, Kelleher Ian

机构信息

The Hull York Medical School, the University of York, York, UK.

Tees, Esk and Wear Valleys NHS Foundation Trust, Darlington, UK.

出版信息

Child Adolesc Ment Health. 2025 Mar 24. doi: 10.1111/camh.12776.

Abstract

There has been much academic interest in 'the clinical high risk for psychosis' (CHR-P) concept. Indeed, as two child and adolescent psychiatrists interested in psychosis prediction and prevention, we enthusiastically embraced the paradigm in our clinical and academic work. However, despite more than two decades of research, there is no definition of CHR-P in adolescence that has proven to be able to usefully predict transition to psychosis. Indeed, research suggests that much, if not all, of the risk associated with CHR diagnoses in adolescents is captured by being help-seeking for mental health problems, rather than being associated with a CHR diagnosis itself. In this commentary, we critique the systematic review by Frearson et al. (2025). In particular, we challenge the conceptualisation around the CHR-P concept, as applied to under 18 s, and the assumptions underpinning it. We also highlight issues with the terminology used when describing the experiences of young people categorised as being at CHR-P. Rather, we make the case for understanding and supporting help-seeking young people with distressing perceptual and ideational disturbance employing a needs-based, person-centred approach.

摘要

学术界对“精神病临床高危”(CHR-P)概念一直很感兴趣。事实上,作为两名关注精神病预测与预防的儿童及青少年精神科医生,我们在临床和学术工作中热情地接受了这一范式。然而,尽管经过了二十多年的研究,但尚无一个已被证明能有效预测青少年向精神病转变的CHR-P在青少年中的定义。实际上,研究表明,青少年中与CHR诊断相关的风险,即便不是全部,也有很大一部分是通过寻求心理健康问题帮助来体现的,而非与CHR诊断本身相关。在这篇评论中,我们对弗里尔森等人(2025年)的系统评价进行批判。特别是,我们质疑将CHR-P概念应用于18岁以下人群时的概念化方式及其背后的假设。我们还强调在描述被归类为处于CHR-P的年轻人经历时所用术语存在的问题。相反,我们主张采用基于需求、以人为本的方法来理解和支持那些因痛苦的感知和观念障碍而寻求帮助的年轻人。

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