Dreyer Camilla Lassen, Fuglsang Jens, Jensen Henrik Kjærulf, Glerup Mia, Bjerre Jesper Vandborg, Deleuran Bent, Dahl Marie Louise Næstholt
Institut for Biomedicin, Aarhus Universitet.
Kvindesygdomme og Fødsler, Aarhus Universitetshospital.
Ugeskr Laeger. 2025 Feb 24;187(9):V07240457. doi: 10.61409/V07240457.
Anti-Sjögren's syndrome type A (SSA)-autoantibodies are present in ½-1% of the population and associated with neonatal lupus erythematosus (NLE), of which congenital atrioventricular (AV) block is the most severe manifestation. The aim of this review is to map the road for an anti-SSA-autoantibody-positive woman from wish to conceive until birth, and beyond. With proper care, it is possible to reduce both the risk of NLE and AV-block, and today children born with NLE and AV-block can lead an almost normal life. It is vital that all doctors know of the autoantibody, treatment, and possible outcome.
抗干燥综合征A（SSA）型自身抗体存在于1/2至1%的人群中，并与新生儿红斑狼疮（NLE）相关，其中先天性房室传导阻滞是最严重的表现。本综述的目的是为抗SSA自身抗体阳性的女性描绘一条从希望怀孕到分娩及之后的路线图。通过适当的护理，可以降低NLE和房室传导阻滞的风险，如今患有NLE和房室传导阻滞的儿童可以过上几乎正常的生活。所有医生了解这种自身抗体、治疗方法及可能的结果至关重要。
