Puggina Anna, Dovizio Melania, Domnich Alexander, Marijam Alen, Veronesi Chiara, Rizzo Caterina, Vicentini Marta, Degli Esposti Luca, Calabrò Giovanna Elisa, Fonseca Maria João
GSK, Verona, Italy.
CliCon S.r.l. Società Benefit, Health, Economics & Outcomes Research, Bologna, Italy.
Hum Vaccin Immunother. 2025 Dec;21(1):2479334. doi: 10.1080/21645515.2025.2479334. Epub 2025 Mar 24.
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection and can lead to severe disease in older adults or those with comorbidities. This analysis aims to evaluate the demographic and clinical burden of RSV hospitalizations among older adults in Italy and inform potential preventative strategies. Adults aged ≥50 years with ≥1 hospitalization discharge diagnosis for RSV from 2010 to 2021 were included. Demographic characteristics before the first RSV hospitalization and clinical outcomes during this hospitalization and the 12 months following are described. Of the 243 patients, mean (SD) age was 73.7 (13.1) years, 40.7% were male, and the most common comorbidities were chronic obstructive pulmonary disease (37.9%), diabetes (21.8%), and heart failure (15.2%). Mean length of index hospitalization was 17.0 days, during which 9.1% of patients died. At index or during the 12-month follow-up, 5.8% had an intensive care unit admission, 61.3% were prescribed antibiotics, 8.2% had a stroke, and 3.3% had an acute myocardial infarction. During the 12-month follow-up, approximately, half of patients experienced worsening of preexisting comorbidities, with notable rates of re-hospitalization and mortality (44.4% and 29.6%). This study shows a high clinical burden of RSV among older adults in Italy, emphasizing a need for improved RSV surveillance, and may guide policymakers and healthcare providers in making informed recommendations for, and implementation of, RSV vaccination in Italy.
呼吸道合胞病毒（RSV）是急性呼吸道感染的主要病因，可导致老年人或合并症患者出现严重疾病。本分析旨在评估意大利老年人RSV住院的人口统计学和临床负担，并为潜在的预防策略提供依据。纳入了2010年至2021年间因RSV至少有1次住院出院诊断的≥50岁成年人。描述了首次RSV住院前的人口统计学特征以及此次住院期间和之后12个月的临床结局。在243例患者中，平均（标准差）年龄为73.7（13.1）岁，40.7%为男性，最常见的合并症为慢性阻塞性肺疾病（37.9%）、糖尿病（21.8%）和心力衰竭（15.2%）。首次住院的平均时长为17.0天，在此期间9.1%的患者死亡。在首次住院时或12个月的随访期间，5.8%的患者入住重症监护病房，61.3%的患者使用了抗生素，8.2%的患者发生中风，3.3%的患者发生急性心肌梗死。在12个月的随访期间，约一半的患者原有合并症恶化，再住院率和死亡率较高（分别为44.4%和29.6%）。本研究显示意大利老年人中RSV的临床负担较重，强调需要加强RSV监测，并可能指导政策制定者和医疗服务提供者就意大利RSV疫苗接种提出明智的建议并加以实施。
