[Chédiak-Higashi syndrome].

As the Chédiak-Higashi Syndrome (CHS) is rare in various species of mammal and occurs almost only in very young to young animals, it is virtually unknown and may therefore pass unnoticed. For this reason, the symptoms as reported for example in man, cattle, cats and mink are brought together and compared in the present paper. The most important symptoms are dilution of the pigment of skin and fur and increased susceptibility to infection. Enlarged granules are found in leukocytes and various other types of cell. The basis for this defect should be sought at the level of the microtubules. Moreover this report is concerned with genetic features of this type of defect. The criteria to be applied in the diagnosis of the CHS are discussed.