Creel D, Collier L L, Leventhal A G, Conlee J W, Prieur D J
Invest Ophthalmol Vis Sci. 1982 Dec;23(6):798-801.
The Chediak-Higashi syndrome (CHS) occurs in mammals, including humans and cats. The CHS is characterized by decreased oculocutaneous pigmentation, enlarged cytoplasmic granules, increased susceptibility to infections, and a hemorrhagic tendency. Ocular anomalies include pale irides and albinotic or subalbinotic fundi. Cats with CHS also have photophobia and prolonged postrotatory nystagmus. Since hypopigmentation of the pigment epithelium is correlated with misrouting of retinal ganglion cells in mammals, visual projections of CHS cats were examined by autoradiographic techniques to determine whether they exhibit abnormal retinogeniculate projections. In CHS cats, misrouted optic projections fragment layer A1 of the dorsal lateral geniculate nucleus into several islands, similar to the disruption of this lamina reported in the Siamese cat.
切-东综合征（CHS）发生于包括人类和猫在内的哺乳动物中。CHS的特征为眼皮肤色素沉着减少、胞质颗粒增大、易感性增加以及出血倾向。眼部异常包括虹膜淡色以及白化病或亚白化病眼底。患有CHS的猫还畏光且旋转后眼震持续时间延长。由于色素上皮的色素减退与哺乳动物视网膜神经节细胞的错路有关，因此通过放射自显影技术检查了CHS猫的视觉投射，以确定它们是否表现出异常的视网膜膝状体投射。在CHS猫中，错路的视投射将背外侧膝状核的A1层分割成几个岛状，类似于暹罗猫中该层的破坏情况。
