Hsia M T, Burant C F, Kreamer B L, Schrankel K R
Toxicology. 1982;24(3-4):231-44. doi: 10.1016/0300-483x(82)90005-1.
The effects of 3,3',4,4'-tetrachloroazobenzene (TCAB) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) on lymphoid organs in male Sprague-Dawley rats were investigated in various acute exposure studies. Significant thymic atrophy was observed in rats 10 days after the i.p. administration of either compound (on days 1 and 5) at a dose of 25 mg/kg. When 8-week-old animals were studied, the relative thymus weight was reduced to 69% and 49% of the control value by the respective treatment of TCAB and TCAOB. In 2 groups of weanling rats the same dosage of TCAOB was able to reduce the relative thymus weight to 31% and 38% of the comparable control animals. In addition, TCAOB causes a decrease in the body weight gain and a decrease in the weights of major organs in the weanling animals. This toxic response cannot be explained solely on the basis of decreased food intake since qualitatively the same results were observed in a pair-feeding experiment. The involvement of glucocorticoid hormones was rejected as the underlying mechanism since adrenalectomy was found to provide no protection towards the degenerative effect seen upon the lymphoid tissues. This investigation constitutes the first study concerning the effects of these 2 environmental and occupational toxicants on lymphoid organs.
在多项急性暴露研究中，对雄性斯普拉格-道利大鼠的淋巴器官进行了3,3',4,4'-四氯偶氮苯（TCAB）和3,3',4,4'-四氯氧化偶氮苯（TCAOB）的影响研究。腹腔注射这两种化合物（第1天和第5天），剂量为25 mg/kg，10天后观察到大鼠胸腺明显萎缩。研究8周龄动物时，经TCAB和TCAOB各自处理后，胸腺相对重量分别降至对照值的69%和49%。在两组断奶大鼠中，相同剂量的TCAOB能够使胸腺相对重量降至可比对照动物的31%和38%。此外，TCAOB导致断奶动物体重增加减少以及主要器官重量减轻。这种毒性反应不能仅基于食物摄入量减少来解释，因为在配对喂养实验中观察到了定性相同的结果。由于发现肾上腺切除术对淋巴组织的退化效应没有保护作用，因此排除了糖皮质激素的参与作为潜在机制。本研究是关于这两种环境和职业毒物对淋巴器官影响的首次研究。
