利用溶酶体应激反应促进健康衰老。
Harnessing lysohormesis for healthy ageing.
作者信息
Tan Jay Xiaojun
机构信息
Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Nat Cell Biol. 2025 Apr;27(4):548-551. doi: 10.1038/s41556-025-01634-9.
Abstract
Dysfunction of lysosomes is emerging as a common pathogenic mechanism underlying normal aging and many age-related diseases. Lysohormesis, the triggering of beneficial adaptations by a mild lysosomal stress for increased lysosomal function and cellular stress resilience, could provide a common solution to many age-related issues.
摘要
溶酶体功能障碍正逐渐成为正常衰老和许多与年龄相关疾病的共同致病机制。溶酶体应激反应，即由轻度溶酶体应激引发有益适应以增强溶酶体功能和细胞应激恢复力，可能为许多与年龄相关的问题提供一个通用解决方案。
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