用于将mRNA递送至大脑的设计脂质。 - Suppr

Suppr

超能文献

Designer lipids for delivering mRNA to the brain.

作者信息

Han Emily L, Safford Hannah C, Mitchell Michael J

机构信息

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Nat Mater. 2025 Mar 24. doi: 10.1038/s41563-025-02184-z.

DOI:10.1038/s41563-025-02184-z

PMID:40128627

Abstract

摘要

相似文献

Designer lipids for delivering mRNA to the brain.用于将mRNA递送至大脑的设计脂质。

Nat Mater. 2025 Mar 24. doi: 10.1038/s41563-025-02184-z.

Intensified synthesis of palm olein designer lipids using sonication.超声强化棕榈仁油设计脂质的合成。

Ultrason Sonochem. 2021 May;73:105478. doi: 10.1016/j.ultsonch.2021.105478. Epub 2021 Feb 2.

Combining designer receptors exclusively activated by designer drugs and neuroimaging in experimental models: A powerful approach towards neurotheranostic applications.结合实验模型中专门被设计药物激活的设计受体和神经影像学：一种用于神经治疗应用的强大方法。

Br J Pharmacol. 2020 Mar;177(5):992-1002. doi: 10.1111/bph.14885. Epub 2020 Feb 3.

Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice.氯氮平-N-氧化物和化合物 21 对实验小鼠睡眠的影响。

Elife. 2023 Mar 9;12:e84740. doi: 10.7554/eLife.84740.

A Method for Remotely Silencing Neural Activity in Rodents During Discrete Phases of Learning.一种在啮齿动物学习的离散阶段远程沉默神经活动的方法。

J Vis Exp. 2015 Jun 22(100):e52859. doi: 10.3791/52859.

Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors.活脑内表达DREADD的神经元的多模态成像及其在诱导多能干细胞衍生神经祖细胞植入中的应用

J Neurosci. 2016 Nov 9;36(45):11544-11558. doi: 10.1523/JNEUROSCI.1279-16.2016.

Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing.用于 mRNA 脂质纳米颗粒血脑屏障转染和穿越的双重筛选的高通量预测平台。

Nano Lett. 2024 Feb 7;24(5):1477-1486. doi: 10.1021/acs.nanolett.3c03509. Epub 2024 Jan 23.

Branched hydrophobic tails in lipid nanoparticles enhance mRNA delivery for cancer immunotherapy.脂质纳米粒中分支的疏水尾部增强了 mRNA 传递用于癌症免疫治疗。

Biomaterials. 2023 Oct;301:122279. doi: 10.1016/j.biomaterials.2023.122279. Epub 2023 Aug 14.

Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection.脂质纳米颗粒在鞘内注射后可增强mRNA向中枢神经系统的递送。

Adv Mater. 2025 May 3:e2417097. doi: 10.1002/adma.202417097.

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson's disease treatment.脑内植入细胞产生的设计细胞外囊泡为帕金森病治疗提供治疗性货物。

Nat Commun. 2018 Apr 3;9(1):1305. doi: 10.1038/s41467-018-03733-8.

引用本文的文献

CloneFast: A simple plasmid design and construction guide for labs venturing into synthetic biology.CloneFast：一份面向涉足合成生物学领域实验室的简单质粒设计与构建指南。

STAR Protoc. 2025 Aug 6;6(3):104025. doi: 10.1016/j.xpro.2025.104025.

本文引用的文献

Barium titanate and lithium niobate permittivity and Pockels coefficients from megahertz to sub-terahertz frequencies.从兆赫兹到亚太赫兹频率下的钛酸钡和铌酸锂的介电常数与普克尔系数。

Nat Mater. 2025 Jun;24(6):868-875. doi: 10.1038/s41563-025-02158-1. Epub 2025 Mar 17.

Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain.用于将mRNA靶向全身递送至大脑的肽功能化脂质纳米颗粒。

Nano Lett. 2025 Jan 15;25(2):800-810. doi: 10.1021/acs.nanolett.4c05186. Epub 2024 Dec 17.

Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles.生物技术：利用脂质纳米粒克服核酸递释的生物学屏障。

PLoS Biol. 2023 Apr 24;21(4):e3002105. doi: 10.1371/journal.pbio.3002105. eCollection 2023 Apr.

Nucleic acid drug vectors for diagnosis and treatment of brain diseases.用于脑疾病诊断和治疗的核酸药物载体。

Signal Transduct Target Ther. 2023 Jan 17;8(1):39. doi: 10.1038/s41392-022-01298-z.

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines.体内脂纳米粒的肝外靶向与细胞内靶向用于未来的纳米药物。

Adv Drug Deliv Rev. 2022 Sep;188:114417. doi: 10.1016/j.addr.2022.114417. Epub 2022 Jul 3.

An ionizable lipid toolbox for RNA delivery.用于 RNA 递送的可离子化脂质工具包。

Nat Commun. 2021 Dec 13;12(1):7233. doi: 10.1038/s41467-021-27493-0.

Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection.通过静脉注射递送至大脑的神经递质衍生类脂（NT-lipidoids）。

Sci Adv. 2020 Jul 24;6(30):eabb4429. doi: 10.1126/sciadv.abb4429. eCollection 2020 Jul.

Amphetamine decorated cationic lipid nanoparticles cross the blood-brain barrier: therapeutic promise for combating glioblastoma.阿扑吗啡修饰阳离子脂质纳米粒穿透血脑屏障：治疗脑胶质母细胞瘤的潜力。

J Mater Chem B. 2020 May 21;8(19):4318-4330. doi: 10.1039/c9tb02700a. Epub 2020 Apr 24.

The global burden of neurological disorders: translating evidence into policy.全球神经障碍负担：将证据转化为政策。

Lancet Neurol. 2020 Mar;19(3):255-265. doi: 10.1016/S1474-4422(19)30411-9. Epub 2019 Dec 5.

The blood-brain barrier: bottleneck in brain drug development.血脑屏障：脑药物研发的瓶颈

NeuroRx. 2005 Jan;2(1):3-14. doi: 10.1602/neurorx.2.1.3.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验